DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	235/511 - (45%)
Similarity:	326/511 - (63%)	Gaps:	12/511 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILFQVA-VALLAILTYYIHRKL-TYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            :||.:| |.::..|.|.:|.|: :|:||:|:|...|..|.|||..:.|..:..:|.|..|.||:
  Fly     1 MLFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFK- 64

  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWRLLR 133
            .:.|..|.:.|....|.:.||:..||::|||||.|.::|.|.|.:|||::.|||.|:|.:||.:|
  Fly    65 GQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFALEGEEWRAMR 129

  Fly   134 NKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSV----LEIRDLVARFTVDVIGTCAFGI 194
            :||:..|||||:|.|...:|.|.......|.:.|.:..|    :||:||.||||.||||:||||:
  Fly   130 HKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGL 194

  Fly   195 QCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVA 259
            :||||:|..|||...|:.....:||.||:..|:.:..:|||||.:......:.:|:...|..||.
  Fly   195 ECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFMSTVKNTVD 259

  Fly   260 VREKEHIKRNDFMDMLIELKNQKEMTLENG---DVVRGLTMEEVLAQAFVFFIAGFETSSSTMGF 321
            .|.|..||||||::.:|||:.:.:...:.|   |:..|||:|::.|||||||:||||||||||..
  Fly   260 YRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSL 324

  Fly   322 ALYELAKNPDIQDKVRAEVEEVIEQHD-QNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAK 385
            .|||||..||||.::|.|:|.|:...| ....|:....:.||:|||.||||.:.::|:|.|...|
  Fly   325 CLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTK 389

  Fly   386 RYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRN 450
            .|.:| :.:.|::.|...:||...|||||.|||||.:|.|.||.|||...|..:|:|||||||||
  Fly   390 DYQIP-NSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRN 453

  Fly   451 CIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKVETV 506
            |||||||::||:|||..|:|.||||..::|..||::..|||:|...||||||||.|
  Fly   454 CIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKVERV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	218/471 (46%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	219/475 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970