DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and Cyp6u1

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	167/510 - (32%)
Similarity:	269/510 - (52%)	Gaps:	29/510 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTK-NIHEIFQDHYN 64
            |.|.:.....|:..|:::...:...|.|:|||||....|..:.||::.:...| :..:..||.|.
  Fly     1 MDLMHRTLLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYT 65

  Fly    65 KFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQW 129
            .:: .:||||||:....|....:||:|..||:..|..:|:::|::.|...:|:|.:|..|||.:|
  Fly    66 AYK-GRAPFVGFYACLKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPLSHNLLQLDGHKW 129

  Fly   130 RLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGI 194
            |.|..|.:..||...|:.:...:..:::.....:.||  ....:.|.:||..:..||:.:.|||:
  Fly   130 RSLHAKSAEVFTPANMQKLLVRLSQISSRIQRDLGEK--SLQTINISELVGAYNTDVMASMAFGL 192

  Fly   195 QCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMR-SYPKLARKLGMVRTAPHIQEFYSRIVTETV 258
                :..:..||..:.:....|.|   :...::. .:|.:||.|.....|.....::.:     |
  Fly   193 ----VGQDNVEFAKWTRNYWADFR---MWQAYLALEFPLIARLLQYKSYAEPATAYFQK-----V 245

  Fly   259 AVREKEHIKRNDF--MDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGF 321
            |:.:.:..:|.|.  :...::|.:..|         :.||..|:..|||.|.:||....::|:.|
  Fly   246 ALSQLQLHRRRDRQPLQTFLQLYSNAE---------KPLTDIEIAGQAFGFVLAGLGPLNATLAF 301

  Fly   322 ALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKR 386
            .|||||:.|::||:.|.|:.:.:|:|....|.||.::|:|..|||:|||||:|..|.|.|.|.|.
  Fly   302 CLYELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLRRATKE 366

  Fly   387 YVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNC 451
            :.|||.. |||..|.:|:||::|||.||.||..|..|.||||..:....||:.|:||||||.|.|
  Fly   367 FEVPGSV-FVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPFGDGLRGC 430

  Fly   452 IGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKVETV 506
            |..||.:.|..:||..|:|..:::..::|..|:.||.:..:|..|..|.|.||.|
  Fly   431 IAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLSVERV 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	153/467 (33%)
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	150/461 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471849
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900