DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and Cyp28a5

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	145/525 - (27%)
Similarity:	254/525 - (48%)	Gaps:	48/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTYILFQVAVALL-AILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIF--QDHYN 64
            :|..|..:.|.|| |:|.:    ...|:::||:|...|.|:.||...:...|. |.|:  .|.|.
  Fly     4 ITLTLVSLVVGLLYAVLVW----NYDYWRKRGVPGPKPKLLCGNYPNMFTMKR-HAIYDLDDIYR 63

  Fly    65 KFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYN--EKDDPISA-HLFNLDG 126
            ::: :|...||.|..:||...||:..||:::.:.:|.||.:..|..|  ||.|.|.| :.|:|.|
  Fly    64 QYK-NKYDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPFSLTG 127

  Fly   127 AQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRD------LVARFTVD 185
            .:|:..|..::...|.|::|.:||    |.|:....:.|.|.|...|..:|      :...||.:
  Fly   128 EKWKTRRADVTPGLTMGRIKTVYP----VTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTE 188

  Fly   186 VIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFM--RSYPKLARKLGMVRTAPHIQE 248
            ::..|..|:...|..|:....:  .|.:.:..:..|.:..|:  .|:|.|:..:.:......::.
  Fly   189 MVTDCVLGLGAESFSDKPTPIM--SKINDLFNQPWTFVLFFILTSSFPSLSHLIKLRFVPVDVER 251

  Fly   249 FYSRIVTETVAVREKE-----HIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFF 308
            |:..::...|..|..:     ..:|:||:|.:::|..:           |.|...::||.:..|.
  Fly   252 FFVDLMGSAVETRRAQLAAGKQFERSDFLDYILQLGEK-----------RNLDNRQLLAYSMTFL 305

  Fly   309 IAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLY 373
            :.||||:::.:...|..|.:|.:.|:.:|.|:...::  |....:|...||.||:..:.||:||:
  Fly   306 LDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQ--DGTIAFEKLSDLPYLDACVQETIRLF 368

  Fly   374 TIVPNLDRMAAKRYVVPGH--PNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAG- 435
            ......:::..:...:|..  ||||:|.|.:|::|......|...:|.|..|:||||...::|.
  Fly   369 PPGFMSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAKT 433

  Fly   436 -RPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGI 499
             |....::.||||||.|||:||..:|.:..:..||..|......||.....|:|...:.|::.||
  Fly   434 FRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDYEPGQIITGLRGGI 498

  Fly   500 YLKVE 504
            :|.:|
  Fly   499 WLDLE 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	133/485 (27%)
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	133/487 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460971
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900