DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	539	Identity:	121/539 - (22%)
Similarity:	230/539 - (42%)	Gaps:	74/539 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFQVAVALLAILTYYIHRKLTYFK---------RRGIPFVAP---HLIRGNM-------EELQKT 52
            ::.|:..||.:|.::....:..||         |:...|..|   |.:.|:|       :.||..
Mouse    21 VYVVSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMYLPNEKGLQNE 85

  Fly    53 KNI----HEIFQDHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEK 113
            |.:    |.|.           ..:||.|.   |...::..:..|.:|....:.......||:..
Mouse    86 KKVLDTMHHII-----------LAWVGPFL---PLLVLVHPDYIKPVLGASAAIAPKDEFFYSFL 136

  Fly   114 DDPISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEK----VPKNSV-- 172
            ...:...|....|.:|...|..|:..|....:|    ..:.:.|:...:||.|    :.:.||
Mouse   137 KPWLGDGLLISKGNKWSRHRRLLTPAFHFDILK----PYMKIFNQCTNIMHAKWRRHLAEGSVTS 197

  Fly   173 LEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFL--YFGKRSLVDKRHGTLLNGFMRSYPKLAR 235
            .::.:.::..|:|.:..|.|... :..::..::::  .....:||.:|...|.:.....|...|.
Mouse   198 FDMFEHISLMTLDSLQKCVFSYN-SDCQERMSDYISSIIELSALVVRRQYRLHHYLDFMYYLTAD 261

  Fly   236 KLGMVRTAPHIQEFYSRIVTE-TVAVREK--------EHIKRNDFMDMLIELKNQKEMTLENGDV 291
            .....:....:..|.:.::.| ..|:|::        :..|..||:|:|:..|:::...|.:
Mouse   262 GRRFRQACDTVHNFTTEVIQERRQALRQQGAEAWLKAKQGKTLDFIDVLLLAKDEEGKELSD--- 323

  Fly   292 VRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHD-QNFTYEC 355
                  |::.|:|..|...|.:|:||.:.:||:.|||.|:.|:|.|.|::||::..: :...::.
Mouse   324 ------EDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDWDD 382

  Fly   356 TKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEP 420
            ...|.:....:.|:||.:..|..:.|...:...:|  ...||..|...::.....||:|.::|:.
Mouse   383 LTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLP--DGRVIPKGIICLVSIYGTHHNPIVWPDS 445

  Fly   421 FEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLV 485
            ..:.|.||.|:....|..:|::||..|||||||..|...:.|:.:||.:..|:.|. .:|..  |
Mouse   446 KVYNPYRFDPDTPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSV-DRTHK--V 507

  Fly   486 YDPKSFVLGVKDGIYLKVE 504
            ......:|..::|::|.||
Mouse   508 RRKPELILRTENGLWLNVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	111/495 (22%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	108/487 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900