DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	130/552 - (23%)
Similarity:	236/552 - (42%)	Gaps:	83/552 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTYIL------FQVAV--ALLAILTYYIHRKLTY-FK---------RRGIPFVAP---HLIRGNM 46
            |.|:|      |:|.|  |||..|.:.:.|.|.. ||         ||...|..|   |.:.|:|
  Rat     8 LLYLLGLEKTAFRVYVLSALLLFLLFLLFRLLLQAFKLFSDFRITCRRLSCFPEPPGRHWLLGHM 72

  Fly    47 -------EELQKTKNI----HEIFQDHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDF 100
                   :.||..|.:    |.|.           ..:||.|.   |...::..:..|.:|....
  Rat    73 SMYLPNEKGLQNEKKVLDTMHHII-----------LAWVGPFL---PLLVLVHPDYIKPVLGASA 123

  Fly   101 SNFSNKGIFYNEKDDPISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHE 165
            :.......||:.....:...|....|.:|...|..|:..|....:|    ..:.:.|:.:.:||.
  Rat   124 AIAPKDEFFYSFLKPWLGDGLLISKGNKWSRHRRLLTPAFHFDILK----PYMKIFNQSVNIMHA 184

  Fly   166 K----VPKNSV--LEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFL--YFGKRSLVDKRHGTL 222
            |    :.:.||  .::.:.|:..|:|.:..|.|... :..:::.::::  .....:||.:|...|
  Rat   185 KWRRHLAEGSVTSFDMFEHVSLMTLDSLQKCVFSYS-SDCQEKLSDYISSIIELSALVVRRQYRL 248

  Fly   223 LNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTE-TVAVRE--------KEHIKRNDFMDMLIEL 278
            .:.....|...|......:....:..|.:.::.: ..|:||        .:..|..||:|:|:..
  Rat   249 HHYLDFIYYLTADGRRFRQACDTVHNFTTEVIQQRRRALRELGAEAWLKAKQGKTLDFIDVLLLA 313

  Fly   279 KNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEV 343
            |:::...|.:         |::.|:|..|...|.:|:||.:.:||:.|||.|:.|||.|.|::||
  Rat   314 KDEEGKELSD---------EDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEV 369

  Fly   344 IEQHD-QNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPS 407
            ::..: :...::....|.:....:.|:||.:..|..:.|...:...:|  ...:|..|...::..
  Rat   370 MKGRELEELDWDDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLP--DGRIIPKGIICLVSI 432

  Fly   408 SAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNF 472
            ...|::|.::|:...:.|.||.|:....|..:|::||..|||||||..|...:.|:.:||.:..|
  Rat   433 YGTHYNPLVWPDSKVYNPYRFDPDIPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRF 497

  Fly   473 KFSTCSKTPNPLVYDPKSFVLGVKDGIYLKVE 504
            :.|. .:|..  |......:|..::|::|.||
  Rat   498 RLSV-DRTRK--VRRKPELILRTENGLWLNVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	111/495 (22%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	106/473 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900