Protein Alignment Cyp6a8 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 140/562 - (24%)
• Similarity: 241/562 - (42%)
• Gaps: 120/562 - (21%)

  Fly     6 ILFQVAVAL----LAILTYYIHRKLTYFKR----RGIPFVA------PHLIRGNMEELQKTKNIH 56
            :|:..|.||    .:::...:.|..:|.::    |.||.||      .|.:      |.|... .
Human    14 LLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHAL------LMKPDG-R 71

  Fly    57 EIFQ---DHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPIS 118
            |.||   ::..::|.  .|.:..:....|...:.:.|..:.||..  |...:|...|...:..:.
Human    72 EFFQQIIEYTEEYRH--MPLLKLWVGPVPMVALYNAENVEVILTS--SKQIDKSSMYKFLEPWLG 132

  Fly   119 AHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFT 183
            ..|....|.:||..|..|:.||.           .::..:|:.:|:|:.   ::| ::.|.....
Human   133 LGLLTSTGNKWRSRRKMLTPTFH-----------FTILEDFLDIMNEQA---NIL-VKKLEKHIN 182

  Fly   184 VDV------IGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGM--- 239
            .:.      |..||..|.|     |.|.....|.:|..|..:   :....|....:.|::.|
Human   183 QEAFNCFFYITLCALDIIC-----ETAMGKNIGAQSNDDSEY---VRAVYRMSEMIFRRIKMPWL 239

  Fly   240 ---------------VRTAPHIQEFYSRIVTETVAVREKE-----------------HIKRNDFM 272
                           .::...:..|.:.::.|    |..|                 ..||..|:
Human   240 WLDLWYLMFKEGWEHKKSLQILHTFTNSVIAE----RANEMNANEDCRGDGRGSAPSKNKRRAFL 300

  Fly   273 DMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVR 337
            |:|:.:.:.:...|.:.|:     .|||  ..|:|  .|.:|:::.:.::||.|..||::|.||.
Human   301 DLLLSVTDDEGNRLSHEDI-----REEV--DTFMF--EGHDTTAAAINWSLYLLGSNPEVQKKVD 356

  Fly   338 AEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQS 402
            .|:::|..:.|:..|.|..|.|:||..|:.|||||:..||...|..::...|.|:.  |::..::
Human   357 HELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYR--VLKGTEA 419

  Fly   403 VIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLAL 467
            |||| .|:|.||..:|.|.||:||||.||.:.||...|::||..|||||||.:|..|:.:..|:.
Human   420 VIIP-YALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSC 483

  Fly   468 LIRNFKFSTCSK-----TPNPLVYDPKSFVLGVKDGIYLKVE 504
            ::|:|...:..|     ....|:..|       .:||::|::
Human   484 ILRHFWIESNQKREELGLEGQLILRP-------SNGIWIKLK 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	120/475 (25%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	122/488 (25%)