Protein Alignment Cyp6a8 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 70/350 - (20%)
• Similarity: 129/350 - (36%)
• Gaps: 54/350 - (15%)

  Fly   378 GEEGDRESSPEVIPVEASPETLCISS-------DSEEERLAKERASIFVPNIEELDRQAKKPPTP 435
            |.:||.....:.:.::|:|.:|.:..       .:.|:|.:.:.....:|.:|..:      |.|
Human    21 GRQGDSLQDLQHLSIKAAPRSLSVPDYGPSLKLGALEDRHSLQSVDSGIPTLEIGN------PEP 79

  Fly   436 VPAQPAE-DTEPEEGEISEDEEPEPE-------PEPAAVPEEQPTEDKEQSGEAEDT---VQMET 489
            ||..... ..:..|.||      .||       |.|:..|......::||......|   ...::
Human    80 VPCSVVHVKRKQSESEI------VPERAFQSACPLPSCTPSAPTCSEREQVVRKSSTFPRTGYDS 138

  Fly   490 AEGEEPAPDAAMEQDKAKADTMEAEEATAKDKSVVLSSGSSDEGDSGGSSSSDSSSSSEAEQDDA 554
            .:...|...|....|.....::   .:...:.|..||..:.|..|...:|:|.:..:.|.:.|..
Human   139 VKLYSPTSKALSRSDNVSVCSV---SSLGTELSTTLSVSNEDILDLMVTSNSSAIVTLENDDDPQ 200

  Fly   555 KDDAPTKLDHSAQDDH--DIVEIHDSGDETLLLEDKPPEEEAKSWNSRWLKSNRVAKVMAASRLG 617
            ..|......:...|.|  |.|...:.|.:..||.   |.....:.|....|.|  |::.....||
Human   201 FTDVTLSSINETSDLHQQDCVAETEEGRKLKLLH---PFSHFFTRNLLARKQN--ARLDRQRDLG 260

  Fly   618 NKVREKLKKKKQIQQAAEQQQQQQQQE--KPADGPEVSSETIANAG--DTTTTATEL---PANVE 675
            .|:..|:..::..|:.:::.|::.:.:  :|:..|........|..  ..:|||..|   |||:.
Human   261 WKLFGKVPLRETAQKDSKKTQKEYEDKAGRPSRPPSPKQNVRKNLDFEPLSTTALILEDRPANLP 325

  Fly   676 LGSVE-------HYRELIAQQENKQ 693
            ....|       .|.|::.|.:.::
Human   326 AKPAEEAQKHRQQYEEMVLQAKKRE 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	26/139 (19%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	61/298 (20%)