DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp6a8 and CYP4A22

DIOPT Version :9

Sequence 1:NP_523749.2 Gene:Cyp6a8 / 36666 FlyBaseID:FBgn0013772 Length:506 Species:Drosophila melanogaster
Sequence 2:NP_001010969.2 Gene:CYP4A22 / 284541 HGNCID:20575 Length:519 Species:Homo sapiens


Alignment Length:533 Identity:129/533 - (24%)
Similarity:223/533 - (41%) Gaps:80/533 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LFQVAVALLAIL------TYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNK 65
            :.||...|:.:|      ..|:||:......:..|....|.:.|:::|.|..:.:..| |:....
Human    18 ILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRI-QERVKT 81

  Fly    66 FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDP------------IS 118
            | .|..|:  :.:.......:.|.:..|.||               .:.||            |.
Human    82 F-PSACPY--WIWGGKVRVQLYDPDYMKVIL---------------GRSDPKSHGSYKFLAPRIG 128

  Fly   119 AHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVM---HEKVPKNSVLEIRDLVA 180
            ..|..|:|..|...|..|:..|.:..:|   |.|..:|:....::   .|.:.::|.||:...|:
Human   129 YGLLLLNGQTWFQHRRMLTPAFHNDILK---PYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVS 190

  Fly   181 RFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRS-----------YPKLA 234
            ..|:|.|...||..|.:...|..::........|.......:.|.|..:           :...|
Human   191 LMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRA 255

  Fly   235 RKLGMVRTAPHIQEFYSRIVTETVAVREKEHIKRN---DFMDMLIELKNQKEMTLENGDVVRGLT 296
            .:|....|...||...:::..|    .|.|.|||.   ||:|:|:..|      :|||.:   |:
Human   256 CQLAHQHTDQVIQLRKAQLQKE----GELEKIKRKRHLDFLDILLLAK------MENGSI---LS 307

  Fly   297 MEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKY 361
            .:::.|:...|...|.:|::|.:.:.||.||.:|..|::.|.|:..::.. ..:.|:.....:.|
Human   308 DKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD-GASITWNHLDQMPY 371

  Fly   362 LNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPE 426
            ....:.|.||||..||.:.|..:.....|...:  :..|..|::....:||:|.::|....|.|.
Human   372 TTMCIKEALRLYPPVPGIGRELSTPVTFPDGRS--LPKGIMVLLSIYGLHHNPKVWPNLEVFDPS 434

  Fly   427 RFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK-FSTCSKTPNPLVYDPKS 490
            ||:|  .:.:.|.|:|||..|.|||||.:|...|.::..||.:..|: ....::.|.|:.    .
Human   435 RFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMA----R 493

  Fly   491 FVLGVKDGIYLKV 503
            .||..|:||:|::
Human   494 LVLKSKNGIHLRL 506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp6a8NP_523749.2 p450 39..503 CDD:278495 121/493 (25%)
CYP4A22NP_001010969.2 p450 52..505 CDD:278495 121/496 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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