DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and Cyp4a12a

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_803125.2	Gene:	Cyp4a12a / 277753	MGIID:	88612	Length:	508	Species:	Mus musculus

Alignment Length:	542	Identity:	127/542 - (23%)
Similarity:	230/542 - (42%)	Gaps:	99/542 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNK 65
            ::|..:||:.|       ..|:||:......:..|....|.:.|:  ::.|.:::    ||...:
Mouse    25 LSLLLLLFKTA-------QLYLHRQWLLSSTQQFPSPPSHWLFGH--KILKDQDL----QDILTR 76

  Fly    66 FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDP------------IS 118
            .:...:....:.:.......|.|.:..|.||               .:.||            |.
Mouse    77 IKNFPSACPQWLWGSKVRIQVYDPDYMKLIL---------------GRSDPKANGSYRFLAPWIG 126

  Fly   119 AHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEK----VPKNSVLEIRDLV 179
            ..|..|||..|...|..|:..|....:| .|..:::   :.:.||.:|    |.::|.|||...:
Mouse   127 RGLLMLDGQTWFQHRRMLTPAFHYDILK-PYTEIMA---DSVRVMLDKWEQIVGQDSTLEIFRHI 187

  Fly   180 ARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGF---------------MRS 229
            ...|:|.|..|||..:.:...|.|.:........|.|.....:.|.|               ..|
Mouse   188 TLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANS 252

  Fly   230 YPKLARKLGMVRTAPHIQEFYSRIVTETVAVREKEHI------KRNDFMDMLIELKNQKEMTLEN 288
            ..|||.        .|..:.   |.:..:.::::|.:      :|.||:|:|:..:      :||
Mouse   253 ACKLAH--------DHTDQV---IKSRRIQLQDEEELEKLKKKRRLDFLDILLFAR------MEN 300

  Fly   289 GDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTY 353
            |   :.|:.:::.|:...|...|.:|::|.:.:..|.||.||:.|.:.|.|::.::.. ..:.|:
Mouse   301 G---KSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGD-GTSITW 361

  Fly   354 ECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYP 418
            .....:.|....:.|.||:|..||::.|..:.....|...:  :..|..|::....:||:|:::|
Mouse   362 NDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRS--LPKGIHVMLSFYGLHHNPTVWP 424

  Fly   419 EPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK-FSTCSKTPN 482
            .|..|.|.||:|..|  |.|.::|||..|.|||||.:|...:.::.:||.:..|: ....::.|.
Mouse   425 NPEVFDPSRFAPGSS--RHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPI 487

  Fly   483 PLVYDPKSFVLGVKDGIYLKVE 504
            |:   |: .||..|:||:|.::
Mouse   488 PI---PR-IVLKSKNGIHLHLK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	119/501 (24%)
Cyp4a12a	NP_803125.2	p450	52..502	CDD:278495	119/503 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900