Protein Alignment Cyp6a8 and Cyp4a8

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_113793.2
• Gene: Cyp4a8 / 266674
• RGDID: 628846
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 557
• Identity: 132/557 - (23%)
• Similarity: 235/557 - (42%)
• Gaps: 110/557 - (19%)

  Fly     2 ALTYILF--------QVAVALLAIL------TYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKT 52
            ||::.:|        |:|..|..:|      .:|:||:......:..|....|...|
  Rat     5 ALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFG-------- 61

  Fly    53 KNIHEI-----FQDHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNE 112
               |:|     |||...:.:...:....:.:..:....|.|.:..|.||               .
  Rat    62 ---HKIPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLIL---------------G 108

  Fly   113 KDDPISAH------------LFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHE 165
            :.||.|.|            |..|:|..|...|..|:..|....:|    ..|.:..:.:.:|.:
  Rat   109 RSDPKSHHSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLK----PYVGIMADSVRIMLD 169

  Fly   166 K----VPKNSVLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAE-----------FLYFGKRSLV 215
            |    |.::|.|||...:...|:|.|..|||..:.:...|.|.:           ..:|..|::.
  Rat   170 KWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIF 234

  Fly   216 DKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVA-VREKEHI------KRNDFMD 273
            .:      |..:.|.....||........|  |...:::....| ::::|.:      :|.||:|
  Rat   235 HQ------NDIIYSLSSNGRKARSAWQLAH--EHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLD 291

  Fly   274 MLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRA 338
            :|:..:      :|||.   .|:.:::.|:...|...|.:|::|.:.:..|.||.||:.|...|.
  Rat   292 ILLFAR------IENGS---SLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRK 347

  Fly   339 EVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSV 403
            |::.::.. ..:.|::....:.|....:.|.||:|..|..:.||.:.....|...:  :..|.:|
  Rat   348 EIQSLLGD-GASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRS--LPKGITV 409

  Fly   404 IIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALL 468
            ::....:||:|:::|.|..|.|.||:||.|  |.|.::|||..|.|||||.:|...:.::.:||.
  Rat   410 MLSFYGLHHNPTVWPNPEVFDPYRFAPESS--RHSHSFLPFSGGARNCIGKQFAMNELKVAVALT 472

  Fly   469 IRNFK-FSTCSKTPNPLVYDPKSFVLGVKDGIYLKVE 504
            :..|: ....::.|.|:   |: .||..|:||||:::
  Rat   473 LLRFELLPDPTRIPIPI---PR-LVLKSKNGIYLRLK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	111/464 (24%)
Cyp4a8	NP_113793.2	CYP4B-like	70..503	CDD:410771	116/477 (24%)