Protein Alignment Cyp6a8 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 136/529 - (25%)
• Similarity: 243/529 - (45%)
• Gaps: 74/529 - (13%)

  Fly     7 LFQVAVALLAILTYYIHRKLTYFKRRGIPFVAP--HLIRGNMEELQ--KTKNIHEIFQDHYNKFR 67
            :|.:|:.||..:..|:.|:......|  ||.||  |...|:.:.:|  ..:.:.||.:.:...|.
Human    19 VFCLALGLLQAIKLYLRRQRLLRDLR--PFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFP 81

  Fly    68 ESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDP-ISAHLFNLDGAQWRL 131
            ....||..||....|       :.||.:|    |....|..:..:...| :...|..|||.:|..
Human    82 FWIGPFQAFFCIYDP-------DYAKTLL----SRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQ 135

  Fly   132 LRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKV--PKNSVLEIRDLVARFTVDVIGTCAF-- 192
            .|..|:..|....:| .|..|::.:.:.|....||:  .:::.:|:.:.:...::|:|..|||
Human   136 HRRLLTPGFHFNILK-AYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 199

  Fly   193 --GIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEF--YSRI 253
              ..|.||..|..|:.::...:.:           |.|.|..|.....:.:.:|....|  .||:
Human   200 ETNCQTNSTHDPYAKAIFELSKII-----------FHRLYSLLYHSDIIFKLSPQGYRFQKLSRV 253

  Fly   254 V---TETVAVREKEHI------------KRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQ 303
            :   |:|:....|:.:            |..||:|:::..|::...:..:.|         |.::
Human   254 LNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDID---------VHSE 309

  Fly   304 AFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDE 368
            ...|.:||.:|.::::.:.||.||.||:.|::.|.||..::.. ..:.|::...::.|....:.|
Human   310 VSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSITWDQLGEMSYTTMCIKE 373

  Fly   369 TLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEES 433
            |.||...||::.|..:|....|  ....:.||.:|::....:||:|:::..|..|.|.|||.|.|
Human   374 TCRLIPAVPSISRDLSKPLTFP--DGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENS 436

  Fly   434 AGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPN---PLVYDPKSFVLGV 495
            ..|...|:|||..|.|||||..|..::.::.:||::.:|:.     ||:   ||.: |..|:|..
Human   437 DQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV-----TPDPTRPLTF-PNHFILKP 495

  Fly   496 KDGIYLKVE 504
            |:|:||.::
Human   496 KNGMYLHLK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	117/456 (26%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	121/476 (25%)
		heme binding region	447..460		7/12 (58%)