DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp6a8 and CYP4X1

DIOPT Version :9

Sequence 1:NP_523749.2 Gene:Cyp6a8 / 36666 FlyBaseID:FBgn0013772 Length:506 Species:Drosophila melanogaster
Sequence 2:NP_828847.1 Gene:CYP4X1 / 260293 HGNCID:20244 Length:509 Species:Homo sapiens


Alignment Length:529 Identity:136/529 - (25%)
Similarity:243/529 - (45%) Gaps:74/529 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LFQVAVALLAILTYYIHRKLTYFKRRGIPFVAP--HLIRGNMEELQ--KTKNIHEIFQDHYNKFR 67
            :|.:|:.||..:..|:.|:......|  ||.||  |...|:.:.:|  ..:.:.||.:.:...|.
Human    19 VFCLALGLLQAIKLYLRRQRLLRDLR--PFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFP 81

  Fly    68 ESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDP-ISAHLFNLDGAQWRL 131
            ....||..||....|       :.||.:|    |....|..:..:...| :...|..|||.:|..
Human    82 FWIGPFQAFFCIYDP-------DYAKTLL----SRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQ 135

  Fly   132 LRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKV--PKNSVLEIRDLVARFTVDVIGTCAF-- 192
            .|..|:..|....:| .|..|::.:.:.|....||:  .:::.:|:.:.:...::|:|..|||  
Human   136 HRRLLTPGFHFNILK-AYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSK 199

  Fly   193 --GIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEF--YSRI 253
              ..|.||..|..|:.::...:.:           |.|.|..|.....:.:.:|....|  .||:
Human   200 ETNCQTNSTHDPYAKAIFELSKII-----------FHRLYSLLYHSDIIFKLSPQGYRFQKLSRV 253

  Fly   254 V---TETVAVREKEHI------------KRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQ 303
            :   |:|:....|:.:            |..||:|:::..|::...:..:.|         |.::
Human   254 LNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDID---------VHSE 309

  Fly   304 AFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDE 368
            ...|.:||.:|.::::.:.||.||.||:.|::.|.||..::.. ..:.|::...::.|....:.|
Human   310 VSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSITWDQLGEMSYTTMCIKE 373

  Fly   369 TLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEES 433
            |.||...||::.|..:|....|  ....:.||.:|::....:||:|:::..|..|.|.|||.|.|
Human   374 TCRLIPAVPSISRDLSKPLTFP--DGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENS 436

  Fly   434 AGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPN---PLVYDPKSFVLGV 495
            ..|...|:|||..|.|||||..|..::.::.:||::.:|:.     ||:   ||.: |..|:|..
Human   437 DQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV-----TPDPTRPLTF-PNHFILKP 495

  Fly   496 KDGIYLKVE 504
            |:|:||.::
Human   496 KNGMYLHLK 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp6a8NP_523749.2 p450 39..503 CDD:278495 126/494 (26%)
CYP4X1NP_828847.1 p450 47..501 CDD:306555 125/494 (25%)
heme binding region 447..460 7/12 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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