DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	140/508 - (27%)
Similarity:	251/508 - (49%)	Gaps:	46/508 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            |::|...::.|..|...|.|   ..||:.|||...|..:.|.:  ......:.:...|.|.|:
  Rat    11 TWVLLATSLMLFYIYGTYSH---GLFKKLGIPGPKPVPLFGTI--FNYGDGMWKFDDDCYKKY-- 68

  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIF----YNEKDDPISAHLFNLDGAQ 128
              ....||:....|...::|.|:.|.:|:|: :|.|:|:..|    :.:|...:|      :..:
  Rat    69 --GKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMGFMKKAITMS------EDEE 125

  Fly   129 WRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFG 193
            |:.||..||.||||||:|.|:|.:....:..:..:..:..|...:.::|:...:::|||...:||
  Rat   126 WKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGEPINMKDIFGAYSMDVITGTSFG 190

  Fly   194 IQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRS---YPKLARKLGMVRTA---PHIQEFYSR 252
            :..:||.:.:..|:...|:.|..:    :.:.|:.|   :|.|.....|:..:   .....|:.:
  Rat   191 VNVDSLNNPQDPFVQKAKKILKFQ----IFDPFLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKK 251

  Fly   253 IVTETVAVR-EKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSS 316
            .|......| :.....|.||:.:::..:|.|....:     :.|:..|:.|||.:|...|::.:|
  Rat   252 FVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQ-----KALSDLEMAAQAIIFIFGGYDATS 311

  Fly   317 STMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDR 381
            :::.|.:||||..|::|.|::.|::..: .:....||:...:::||:.|::|:||||.|...|||
  Rat   312 TSISFIMYELATRPNVQKKLQNEIDRAL-PNKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDR 375

  Fly   382 MAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGD 446
            ::.|...:.|   ..|..|..|.||...:|.:|..:.||.||.|||||.|.........:||||:
  Rat   376 VSKKDVEING---VFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGN 437

  Fly   447 GPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPL------VYDPKSFVL 493
            |||||||:||..:..::.:..:::||....|.||..||      ::.|:..::
  Rat   438 GPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQPIFQPEGPII 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	129/473 (27%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	125/447 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770