Protein Alignment Cyp6a8 and Tbxas1

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_036819.1
• Gene: Tbxas1 / 24886
• RGDID: 3826
• Length: 533
• Species: Rattus norvegicus
• Alignment Length: 534
• Identity: 144/534 - (26%)
• Similarity: 258/534 - (48%)
• Gaps: 51/534 - (9%)

  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            |.:...::|.|||:|.:|.....:..::.||....|....||:...::.      |.:.:.:.||
  Rat    14 TVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQG------FWESHLELRE 72

  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNK---GIFYNEKDDP--ISAHLFNLDGAQ 128
            ...|..|::..:.....:.|.::.|::|:::||||||:   |:      :|  |:..:..|...:
  Rat    73 RYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGL------EPKLIADSVLMLRDRR 131

  Fly   129 WRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFG 193
            |..:|..|.|.|:..|:..|.|.:.......::.:..........:|:.....||.:|:.:.|||
  Rat   132 WEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFG 196

  Fly   194 IQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMV---RTAPHIQEFYSRIVT 255
            |:.||....:..|:...:|.........|| ..:.|:|.:...|..:   :....:..|::.::.
  Rat   197 IEVNSQDAPEDPFVQHCQRVFAFSTPRPLL-ALILSFPSIMVPLARILPNKNRDELNGFFNTLIR 260

  Fly   256 ETVAVREKE--HIKRNDFMDMLIEL-KNQKEMTLENGDVV-----------------------RG 294
            ..:|:|:|:  ..:|.||:.|:::. ::...:.:|..|:|                       :.
  Rat   261 NVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKP 325

  Fly   295 LTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDL 359
            ||::|:..|||:|.|||.|.:::|:.|..|.||.:|:.|:::..||:..:|:|.........:.|
  Rat   326 LTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGL 390

  Fly   360 KYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFR 424
            .||:.|:.||||:|.......|.||:...|.|..   |.||..:.|...|:||||..:|.|..|.
  Rat   391 PYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQH---IPAGSVLEIAVGALHHDPEHWPNPETFD 452

  Fly   425 PERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPK 489
            ||||:.|....:....:||||.|||:|:|:|.|.:..::.|..::..|:|..|.:|..||..:.|
  Rat   453 PERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESK 517

  Fly   490 SFVLGVKDGIYLKV 503
            | .|..|:|:|:|:
  Rat   518 S-ALCPKNGVYVKI 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	127/463 (27%)
Tbxas1	NP_036819.1	cytochrome_P450	74..527	CDD:477761	127/463 (27%)