DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and cyp-13A11

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_499704.1	Gene:	cyp-13A11 / 184472	WormBaseID:	WBGene00008809	Length:	517	Species:	Caenorhabditis elegans

Alignment Length:	537	Identity:	144/537 - (26%)
Similarity:	239/537 - (44%)	Gaps:	103/537 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESK 70
            ||..|..:::.|::||.. ..||::|.|||....:...|:..::          .||.|
Worm     3 ILLFVVSSVVGIVSYYFW-TWTYWRRCGIPGPQGYPFLGSALDM----------MDHEN------ 50

  Fly    71 APFVGFFFFQSP-------------AAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAH-- 120
            .||:....:.|.             ...:.|..|..::.:|.:.|      ||....:||...
Worm    51 PPFLQLKKWTSQYGKVYGITEGLLRTLVISDTNLIHEVFVKQYDN------FYGRNLNPIQGDPN 109

  Fly   121 ------LFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLV 179
                  ||:..|.:|:.||...:.||:|..::.:..||...|.|.:..:.:.......:::.:..
Worm   110 REKRVTLFSAQGHRWKRLRTIANPTFSSNNLRKIQVTVEDSALELLRHIEQHTAGGKAIDVLEYF 174

  Fly   180 ARFTVDVIGTCAFGIQCNSL----------RDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYP--- 231
            ..||:||||..|.| |.:||          ||      .|||     .|....|:|.:  :|
Worm   175 QEFTMDVIGRIAMG-QPDSLMFKNPLLPCARD------VFGK-----PRTALFLSGIL--FPWIG 225

  Fly   232 KLARKLG--------------MVRTAPHI-QEFYSRIVTETVAVREKEHIKRNDFMDMLIELKNQ 281
            .:.||:.              |.:||..: |....|:..|...:...|   ..||:|:.::.|:.
Worm   226 PMIRKVVFYFTNVFNNPAAQIMYQTANAVEQRIKQRMAEEKAGIDPGE---PQDFIDLFLDAKSD 287

  Fly   282 KEMTLENGD--------VVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRA 338
             :|.|||.:        |.|.||.:||:.|.|||.||||:|::.::.::.:.||.:|..|.|::.
Worm   288 -DMELENNEDFTKAGVKVTRQLTKDEVVGQCFVFLIAGFDTTALSLSYSSFLLATHPKAQKKLQE 351

  Fly   339 EVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSV 403
            |::.  |..|...|::....|||:..|:.||||:|.:....:.....|....|  |:.||.|..:
Worm   352 EIDR--ECADPEVTFDQLSKLKYMECVIKETLRMYPLGALANSRRCMRSTKIG--NYEIEKGVDI 412

  Fly   404 IIPSSAIHHDPSIYPEPF-EFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLAL 467
            :..:..:|:|.||:.|.. ||:|||:...:........::|||.|||.|||:|...|:.::.|:.
Worm   413 LCDTWTLHYDKSIWGEDAEEFKPERWESGDEHFYQKGGYIPFGLGPRQCIGMRLAYMEEKLLLSH 477

  Fly   468 LIRNFKFSTCSKTPNPL 484
            ::|.:....|:||..||
Worm   478 ILRKYTLEVCNKTQIPL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	132/504 (26%)
cyp-13A11	NP_499704.1	p450	31..506	CDD:278495	133/508 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28638
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm4759
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730