Protein Alignment Cyp6a8 and cyp-25A4

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_497779.1
• Gene: cyp-25A4 / 183248
• WormBaseID: WBGene00007967
• Length: 501
• Species: Caenorhabditis elegans
• Alignment Length: 530
• Identity: 143/530 - (26%)
• Similarity: 239/530 - (45%)
• Gaps: 88/530 - (16%)

  Fly     6 ILFQVAVALLAILTYYIHRKLTYFKRR---GIPFVAPHLIRGNMEELQ---------KTKNIHEI 58
            |:..:...::..::|.|.|:...||.|   |||....|.:.||:..::         .|...|..
 Worm     5 IISTIFFTIITFISYSIWRRHAIFKLRSSIGIPGPPVHWLWGNLNIIKDRVSRLGYNDTTQWHPT 69

  Fly    59 FQDHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNK---GIF-YNEKDDPISA 119
            ....|       .|..|.:........|.:.|..|:|.|::|||||::   .|| .|:.:..:
 Worm    70 LHTKY-------GPIFGLYCGTQLHITVSEEEDIKEIFIQNFSNFSDRMTPDIFGMNQLNQSL-- 125

  Fly   120 HLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTV 184
             |.|.....|:..|:.::..|::||||.|:.|:||..:.|:.|:.||.......:|.:.....::
 Worm   126 -LQNTYATGWKHTRSAIAPIFSTGKMKAMHETLVSKIDIFLEVLKEKSSSGQKWDIFENFQSLSL 189

  Fly   185 DVIGTCAFGIQCNSLRDEKAEFLYFGKRSL---VDKRHGTLLN------------GFMRSYPKL- 233
            |:||.|||.|..|..|| :.:..|...|..   ||.:...:|.            .|:..:..|
 Worm   190 DIIGKCAFAIDSNCQRD-RTDLFYVQARKFVGAVDLKKSWILPVSLILPELSWLWRFLYKFSDLS 253

  Fly   234 ARKLGMVRTAPHIQEFYSRIVTETVAVREKEHIKR-----NDFMDMLIELKNQKEMTLENGDVVR 293
            |.:|.:|:   .:.:.|.|              :|     ||..|:|        ..|...:.:.
 Worm   254 AAELPLVK---GLVDLYDR--------------RRAGEGGNDSTDLL--------NLLIRRETIG 293

  Fly   294 GLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKD 358
            .:|..||:...|.|.|||:||:|:.|.|:.|.||:.|.:|.|:..|:::..|....|  |:...:
 Worm   294 KMTQREVIENCFAFLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKTKENAGLN--YDSIHN 356

  Fly   359 LKYLNQVLDETLRLYTIVPNL-DRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFE 422
            :|||:.|..|:||.|....:. :|:......:.|.   :.....::.:....||.:|:.:..|.|
 Worm   357 MKYLDCVYKESLRFYPPTTHFTNRVCLNDMTIRGQ---IYPEDSTLKVQPYTIHRNPANWESPDE 418

  Fly   423 FRPERFSP-EESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTP----- 481
            |:||||.. ||.:.  |:.|:|||.|||.|:|:||.:|:.:..:|.|:..|:.|.....|
 Worm   419 FQPERFENWEEKSS--SLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFELSLVPGDPPMIPE 481

  Fly   482 -NPLVYDPKS 490
             |.:::.|:|
 Worm   482 TNGVIFRPRS 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	127/454 (28%)
cyp-25A4	NP_497779.1	CYP3A-like	73..494	CDD:410678	128/462 (28%)