DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	161/520 - (30%)
Similarity:	263/520 - (50%)	Gaps:	47/520 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            |::|..:::.||.:...:.|   ..||:.|||...|....|.:  |...|...|     ::|:..
  Rat    11 TWLLLVISLVLLYLYGTHSH---GIFKKLGIPGPKPLPFLGTI--LAYRKGFWE-----FDKYCH 65

  Fly    69 SK-APFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNK------GIFYNEKDDPISAHLFNLD 125
            .| ....|.:..:.|...:.|.::.|.:|:|: :|.|:|:      ||.  :|...||      :
  Rat    66 KKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPVGIL--KKAISIS------E 122

  Fly   126 GAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTC 190
            ..:|:.:|..||.||||||:|.|:|.:....:..:..|.:...:.....::|:...:::|||...
  Rat   123 DEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITAT 187

  Fly   191 AFGIQCNSLRDEKAEFLYFGKRSL-VDKRHGTLLNGFMRSYP---KLARKLGMVRTAPHIQEFYS 251
            :||:..:||.:.:..|:...|:.| .|......|:  :..:|   .|...|.:......:.:|:.
  Rat   188 SFGVNVDSLNNPQDPFVEKIKKLLKFDIFDPLFLS--VTLFPFLTPLFEALNVSMFPRDVIDFFK 250

  Fly   252 RIVTETVAVREKEHIK-RNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETS 315
            ..|......|.||..| |.||:.::|..:|.|..     |..:.|:..|::||:.:|..||:||:
  Rat   251 TSVERMKENRMKEKEKQRMDFLQLMINSQNSKVK-----DSHKALSDVEIVAQSVIFIFAGYETT 310

  Fly   316 SSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLD 380
            ||.:.|.||.||.:||||.|::.|::..: .:..:.||:....::||:.|::||||||.|...|:
  Rat   311 SSALSFVLYLLAIHPDIQKKLQDEIDAAL-PNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLE 374

  Fly   381 RMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFG 445
            |:......:.|   ..|..|..|:||:.|:|.||..:|||.||||||||.:.........:||||
  Rat   375 RVCKTDVEING---VFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFG 436

  Fly   446 DGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKV----ETV 506
            :|||||||:||..|..::.|..:::||.|..|.:|..||... |..:|..:..:.|||    |||
  Rat   437 NGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLS-KQGLLQPEKPLLLKVVSRDETV 500

Fly 507 506
Rat 501 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	146/476 (31%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	147/480 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770