Protein Alignment Cyp6a8 and CYP8B1

DIOPT Version :9

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_004382.2
• Gene: CYP8B1 / 1582
• HGNCID: 2653
• Length: 501
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 116/537 - (21%)
• Similarity: 209/537 - (38%)
• Gaps: 118/537 - (21%)

  Fly    13 ALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKT----KNIHEIFQDHYNKFRESKAPF 73
            |||.::..|:  .|....|:..|: .|.|.:|.:..|...    ||:.|..:....|..:.....
Human    10 ALLVVIAGYL--CLPGMLRQRRPW-EPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTKHGDVFTVQ 71

  Fly    74 VG---FFFFQSPAAF---------VIDL-ELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLD 125
            :|   |.|...|.:|         .:|. :.||::::|.|...|.:|       |....|
Human    72 LGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQG-------DHEMIH----- 124

  Fly   126 GAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMT---------VMHEKVPKNSVLEIRDLVAR 181
            .|..:.||.       .|...|....:.|::...:|         ..||           |.:.|
Human   125 SASTKHLRG-------DGLKDLNETMLDSLSFVMLTSKGWSLDASCWHE-----------DSLFR 171

  Fly   182 FTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRS--YPKLARKLGMVRTAP 244
            |...::.|..:.......:|::.:.|..|:..:..::...|...|:.|  :|:...::|
Human   172 FCYYILFTAGYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVG------ 230

  Fly   245 HIQEFYSRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFI 309
            .:|..:.::::.:.: :|||.|..        .|.|..:...|.|       :...:...|.|.:
Human   231 RLQRLFHKMLSVSHS-QEKEGISN--------WLGNMLQFLREQG-------VPSAMQDKFNFMM 279

  Fly   310 --AGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIE----QHDQNFTYE--CTKDLKYLNQVL 366
              |....:..|..:||..|.|:|:....||.|..:|:.    :..|:|.::  ..:....|:.|:
Human   280 LWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVV 344

  Fly   367 DETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQS---------VIIPSSAIHHDPSIYPEPFE 422
            :||||| ...|.|.|:..:.|.:.      :.:||.         .:.|..::|.||.|:|||..
Human   345 EETLRL-RAAPTLLRLVHEDYTLK------MSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTV 402

  Fly   423 FRPERF-SPEES-------AGRPSVAW-LPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCS 478
            |:.:|| :|..|       .|:....: :|:|.|...|.|..|...:.::.:.|::.:|......
Human   403 FKYDRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVD 467

  Fly   479 -KTPNPLVYDPKSFVLG 494
             .||.|.| ||:.:..|
Human   468 PDTPLPHV-DPQRWGFG 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	109/511 (21%)
CYP8B1	NP_004382.2	p450	41..493	CDD:299894	106/503 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6362
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950