Protein Alignment Cyp6a8 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 157/514 - (30%)
• Similarity: 270/514 - (52%)
• Gaps: 42/514 - (8%)

  Fly     4 TYILFQVAVALLAILTYYIHRKLTY--FKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKF 66
            |::|..|::.||     |::...|:  |||.|||...|..:.||:  |...:.:.:...:.|.|:
Human    11 TWLLLAVSLVLL-----YLYGTRTHGLFKRLGIPGPTPLPLLGNV--LSYRQGLWKFDTECYKKY 68

  Fly    67 RESKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIFYNEKDDPI---SAHLFNLDGA 127
            .:....:.|    |.|...:.|.::.:.:|:|: :|.|:|:     ....|:   .:.:...:..
Human    69 GKMWGTYEG----QLPVLAITDPDVIRTVLVKECYSVFTNR-----RSLGPVGFMKSAISLAEDE 124

  Fly   128 QWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAF 192
            :|:.:|:.||.||||||:|.|:|.:....:..:..:..:..|...:.::|:...:::|||...:|
Human   125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189

  Fly   193 GIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMR--SYPKLA---RKLGMVRTAPHIQEFYSR 252
            |:..:||.:.:..|:...|:.|   :.|.|...|:.  .:|.|.   ..|.:.........|.|:
Human   190 GVNIDSLNNPQDPFVESTKKFL---KFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251

  Fly   253 IVTETVAVREKEHIK-RNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSS 316
            .|......|..:..| |.||:.::|:.:|.||.     :..:.|:..|:.||:.:|..||:||:|
Human   252 SVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKET-----ESHKALSDLELAAQSIIFIFAGYETTS 311

  Fly   317 STMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDR 381
            |.:.|.|||||.:||:|.|::.|::.|:...... ||:....::||:.|::|||||:.:...|:|
Human   312 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRLER 375

  Fly   382 MAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGD 446
            ...|...:.|   ..|..|..|:||:.|:||||..:.||.||||||||.::.:..|.: :.|||.
Human   376 TCKKDVEING---VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI-YTPFGT 436

  Fly   447 GPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKVET 505
            |||||||:||..|..::.|..:::||.|..|.:|..||..|.:. :|..:..|.|||::
Human   437 GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG-LLQPEKPIVLKVDS 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	134/439 (31%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	136/446 (30%)