DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	514	Identity:	157/514 - (30%)
Similarity:	270/514 - (52%)	Gaps:	42/514 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYILFQVAVALLAILTYYIHRKLTY--FKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKF 66
            |::|..|::.||     |::...|:  |||.|||...|..:.||:  |...:.:.:...:.|.|:
Human    11 TWLLLAVSLVLL-----YLYGTRTHGLFKRLGIPGPTPLPLLGNV--LSYRQGLWKFDTECYKKY 68

  Fly    67 RESKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIFYNEKDDPI---SAHLFNLDGA 127
            .:....:.|    |.|...:.|.::.:.:|:|: :|.|:|:     ....|:   .:.:...:..
Human    69 GKMWGTYEG----QLPVLAITDPDVIRTVLVKECYSVFTNR-----RSLGPVGFMKSAISLAEDE 124

  Fly   128 QWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAF 192
            :|:.:|:.||.||||||:|.|:|.:....:..:..:..:..|...:.::|:...:::|||...:|
Human   125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189

  Fly   193 GIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMR--SYPKLA---RKLGMVRTAPHIQEFYSR 252
            |:..:||.:.:..|:...|:.|   :.|.|...|:.  .:|.|.   ..|.:.........|.|:
Human   190 GVNIDSLNNPQDPFVESTKKFL---KFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251

  Fly   253 IVTETVAVREKEHIK-RNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSS 316
            .|......|..:..| |.||:.::|:.:|.||.     :..:.|:..|:.||:.:|..||:||:|
Human   252 SVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKET-----ESHKALSDLELAAQSIIFIFAGYETTS 311

  Fly   317 STMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDR 381
            |.:.|.|||||.:||:|.|::.|::.|:...... ||:....::||:.|::|||||:.:...|:|
Human   312 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRLER 375

  Fly   382 MAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGD 446
            ...|...:.|   ..|..|..|:||:.|:||||..:.||.||||||||.::.:..|.: :.|||.
Human   376 TCKKDVEING---VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI-YTPFGT 436

  Fly   447 GPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKVET 505
            |||||||:||..|..::.|..:::||.|..|.:|..||..|.:. :|..:..|.|||::
Human   437 GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG-LLQPEKPIVLKVDS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	142/473 (30%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	143/477 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720