DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and CYP3A7

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens

Alignment Length:	516	Identity:	156/516 - (30%)
Similarity:	262/516 - (50%)	Gaps:	45/516 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYILFQVAVALLAILTYYIHRKLTY--FKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKF 66
            |::|..|::.||     |::...|:  ||:.|||...|....||  .|...|.......:.|.|:
Human    11 TWLLLAVSLILL-----YLYGTRTHGLFKKLGIPGPTPLPFLGN--ALSFRKGYWTFDMECYKKY 68

  Fly    67 RESKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIFYNEKDDPISAHLFN----LDG 126
            |:    ..|.:..|.|...:.|.::.|.:|:|: :|.|:|:..|     .|: ..:.|    .:.
Human    69 RK----VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF-----GPV-GFMKNAISIAED 123

  Fly   127 AQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCA 191
            .:|:.:|:.||.||||||:|.|.|.:....:..:..:..:......:.::.:...:::|||.:.:
Human   124 EEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTS 188

  Fly   192 FGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRS---YPKLA---RKLGMVRTAPHIQEFY 250
            ||:..:||.:.:..|:...|:.|    ....|:.|:.|   :|.|.   ..|.:......:..|.
Human   189 FGVSIDSLNNPQDPFVENTKKLL----RFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFL 249

  Fly   251 SRIVTETVAVREKEHIK-RNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFET 314
            ::.|.:....|.||..| |.||:.::|:.:|.|:     .:..:.|:..|::||:.:|..||:||
Human   250 TKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKD-----SETHKALSDLELMAQSIIFIFAGYET 309

  Fly   315 SSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNL 379
            :||.:.|.:||||.:||:|.||:.|::.|:...... ||:....|:||:.|::|||||:.:...|
Human   310 TSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRL 373

  Fly   380 DRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPF 444
            :|:..|...:.|   ..|..|..|:|||..:||||..:.||.:|.|||||.:.........:.||
Human   374 ERVCKKDVEING---MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435

  Fly   445 GDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKVET 505
            |.|||||||:||..:..::.|..:::||.|..|.:|..||.......:|..|. |.||.|:
Human   436 GSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKP-IVLKAES 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	142/475 (30%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	142/478 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820