Protein Alignment Cyp6a8 and Cyp4a14

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_031848.1
• Gene: Cyp4a14 / 13119
• MGIID: 1096550
• Length: 507
• Species: Mus musculus
• Alignment Length: 538
• Identity: 124/538 - (23%)
• Similarity: 222/538 - (41%)
• Gaps: 103/538 - (19%)

  Fly     7 LFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESKA 71
            |..:.:.|...:.:|:.|:......:..|.:..|.:.|                 |:.|.:|.:.
Mouse    24 LLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWG-----------------HHLKDKELQQ 71

  Fly    72 PFVGFFFFQSPA----------AFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFN--- 123
            ..:....|.|..          ..:.|.:..|.:|               .:.||.::.::.
Mouse    72 ILIWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVL---------------GRSDPKASGIYQFFA 121

  Fly   124 ---------LDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPK----NSVLEI 175
                     |:|.:|...|..|:..|....:|    ..|.:..:.:.:|.:|..|    :..|||
Mouse   122 PWIGYGLLLLNGKKWFQHRRMLTPAFHYDILK----PYVKIMADSVNIMLDKWEKLDGQDHPLEI 182

  Fly   176 RDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGT---LLNGF--------MRS 229
            ...|:..|:|.:..|||..|.:...||.:: ||  .:::.|..:.|   |.|.|        |.|
Mouse   183 FHCVSLMTLDTVMKCAFSYQGSVQLDENSK-LY--TKAVEDLNNLTFFRLRNAFYKYNIIYNMSS 244

  Fly   230 YPKL---ARKLGMVRTAPHIQEFYSRIVT--ETVAVREKEHIKRNDFMDMLIELKNQKEMTLENG 289
            ..:|   |.::....|...|:...|::..  |....|:|.|:   ||:|:|:..:.:...:|.:
Mouse   245 DGRLSHHACQIAHEHTDGVIKMRKSQLQNEEELQKARKKRHL---DFLDILLFARMEDRNSLSD- 305

  Fly   290 DVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYE 354
                    |::.|:...|...|.:|::|.:.:..|.||.:|:.|.:.|.||:.::.. ..:.|::
Mouse   306 --------EDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGD-GTSVTWD 361

  Fly   355 CTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPE 419
            ....:.|....:.|.||||..|.::.|..:.....|...:  |..|.:..|....:||:|..:|.
Mouse   362 HLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGRS--IPKGITATISIYGLHHNPRFWPN 424

  Fly   420 PFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK-FSTCSKTPNP 483
            |..|.|.||:|:.|  ..|.|:|||..|.|||||.:|...:.::.:||.:..|: ....::.|.|
Mouse   425 PKVFDPSRFAPDSS--HHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVP 487

  Fly   484 LVYDPKSFVLGVKDGIYL 501
            :.    ..||..|:||:|
Mouse   488 IA----RLVLKSKNGIHL 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	112/472 (24%)
Cyp4a14	NP_031848.1	CYP4B-like	69..502	CDD:410771	114/476 (24%)