Protein Alignment Cyp6a8 and Cyp4a12b

DIOPT Version :9

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_758510.2
• Gene: Cyp4a12b / 13118
• MGIID: 3611747
• Length: 508
• Species: Mus musculus
• Alignment Length: 544
• Identity: 132/544 - (24%)
• Similarity: 235/544 - (43%)
• Gaps: 103/544 - (18%)

  Fly     1 MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNK 65
            ::|..:||:.|       ..|:||:......:..|....|.:.|:  ::.|.:::    ||...:
Mouse    25 LSLLLLLFKTA-------QLYLHRQWLLSSTQQFPSPPSHWLFGH--KILKDQDL----QDILTR 76

  Fly    66 FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAH---------- 120
            .:...:....:.:.......|.|.:..|.||               .:.|| .||
Mouse    77 IKNFPSACPQWLWGSKVRIQVYDPDYMKLIL---------------GRSDP-KAHGSYRFLAPWI 125

  Fly   121 ---LFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEK----VPKNSVLEIRDL 178
               |..|||..|...|..|:..|....:| .|..:::   :.:.||.:|    |.::|.|||...
Mouse   126 GRGLLLLDGQTWFQHRRMLTPAFHYDILK-PYTEIMA---DSVHVMLDKWEQIVGQDSTLEIFQH 186

  Fly   179 VARFTVDVIGTCAFGIQCNSLRDEKAE-------------FL----YFGKRSLVDK--RHGTLLN 224
            :...|:|.|..|||..:.:...|.|.:             ||    .|.:..::.:  .:|.|.|
Mouse   187 ITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLAN 251

  Fly   225 GFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVAVREKEHIK---RNDFMDMLIELKNQKEMTL 286
            .        |.:|....|...|:...|::..|    .|.|.:|   |.||:|:|:..:      :
Mouse   252 S--------ACQLAHDHTDQVIKSRRSQLQDE----EELEKLKKKRRLDFLDILLFAR------M 298

  Fly   287 ENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNF 351
            |||   :.|:.:::.|:...|...|.:|::|.:.:..|.||.||:.|.:.|.|::.::.. ..:.
Mouse   299 ENG---KSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGD-GASI 359

  Fly   352 TYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSI 416
            |:.....:.|....:.|.||:|..||::.|..:.....|...:  :..|..|::....:||:|::
Mouse   360 TWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRS--LPKGIHVMLSFYGLHHNPTV 422

  Fly   417 YPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK-FSTCSKT 480
            :|.|..|.|.||:|..|  |.|.::|||..|.|||||.:|...:.::.:||.:..|: ....::.
Mouse   423 WPNPEVFDPSRFAPGSS--RHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRV 485

  Fly   481 PNPLVYDPKSFVLGVKDGIYLKVE 504
            |.|:   |: .||..|:||:|.::
Mouse   486 PIPI---PR-IVLKSKNGIHLHLK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	124/503 (25%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	120/486 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900