Protein Alignment Cyp6a8 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Alignment Length: 486
• Identity: 122/486 - (25%)
• Similarity: 221/486 - (45%)
• Gaps: 47/486 - (9%)

  Fly     6 ILFQVAVALLA--ILTYYIHRKLTYFKR-RGIPFVAPHLIRGNMEEL-QKTKNIHEIFQDHYNKF 66
            :|...:..|||  :...::||..:.::. .|.|  .|..:.|::... :|.::...:.||.:..:
Mouse     5 LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPP--RPSFLLGHLPYFWKKDEDCGRVLQDVFLDW 67

  Fly    67 RESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLF------NLD 125
            .:...|.|....|...:..|...|..|:.|:....|..:|  .|..........||      ..|
Mouse    68 AKKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSK--MYRALQTVFGERLFGQGLVSECD 130

  Fly   126 GAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTC 190
            ..:|...|..:...|:...:..:..|....|.:.:.::..|....:.:.::|::...|:|::...
Mouse   131 YGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDILAKA 195

  Fly   191 AFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKL-GMVRTAPHIQEFYS--R 252
            |||::.:.|         .|.:..:.:....:|.|...|...||:.: |..:....|:|...  |
Mouse   196 AFGMETSML---------LGAQKPLSQAVKVMLEGISASRNTLAKFMPGKRKQLREIRESIRLLR 251

  Fly   253 IVTETVAVREKEHIKRNDFM--DMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFV-FFIAGFET 314
            .|.:....|.:|.:||.:.|  |:|.::...:|          |...:|||...|| |||||.||
Mouse   252 QVGKDWVQRRREALKRGEDMPADILTQILKAEE----------GAQDDEVLLDNFVTFFIAGHET 306

  Fly   315 SSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNL 379
            |::.:.|.:.||::.|:|..:::|||:||:.. .::..||....|:||:|||.|:||||......
Mouse   307 SANHLAFTVMELSRQPEIVARLQAEVDEVVGS-KRHLDYEDLGRLQYLSQVLKESLRLYPPAWGT 370

  Fly   380 DRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIY-PEPFEFRPERFSPEESAGRPSVAWLP 443
            .|:..:..::.|    |...|.:.::.|:.:......| .:|..|.|:||.|  .|.:|...:.|
Mouse   371 FRLLEEETLIDG----VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFP 429

  Fly   444 FGDGPRNCIGLRFGQMQARIGLALLIRNFKF 474
            |..|.|:|||.:|.||:.::.:|.|::..:|
Mouse   430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRIEF 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	109/418 (26%)
Cyp46a1	NP_034140.1	CYP46A1-like	61..484	CDD:410706	111/428 (26%)