Protein Alignment Cyp6a8 and Cyp3a16

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_031846.2
• Gene: Cyp3a16 / 13114
• MGIID: 106099
• Length: 504
• Species: Mus musculus
• Alignment Length: 513
• Identity: 163/513 - (31%)
• Similarity: 261/513 - (50%)
• Gaps: 51/513 - (9%)

  Fly    12 VALLAILTYYIHRKLT----YFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESKAP 72
            :.||||:...::|..|    .||::|||...|....|.:  |...|.:.:...:.|.|:.::
Mouse    12 LVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGTV--LNYYKGLWKFDMECYEKYGKT--- 71

  Fly    73 FVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIFYNEKDDPI---SAHLFNLDGAQWRLLR 133
             .|.|..|.|...:.|.|..|.:|:|: ||.|:|:..|:     |:   |..:......:|:..|
Mouse    72 -WGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFF-----PVGIMSKSISLAKDEEWKRYR 130

  Fly   134 NKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGIQCNS 198
            ..||.|||||.:|.|:|.:....:..:..:.::..|...:.::|::..:::|||.:..||:..:|
Mouse   131 ALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNIDS 195

  Fly   199 LRDEKAEFL----------YFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRI 253
            |.:.:..|:          ||...||     ...|..|:   ..:...|.:........||:.:.
Mouse   196 LNNPEDPFVENAKKVLRFDYFDPLSL-----SVALFPFL---TPIYEMLNICMFPKDSIEFFKKF 252

  Fly   254 V---TETVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETS 315
            |   ||.....:::|  |.||:.:::|..|:.    ::.|..:.|:..|:.||:.:|..||:||:
Mouse   253 VDRMTENRLDSKQKH--RVDFIYLMMEAYNKS----KDKDSHKALSEIEITAQSIIFIFAGYETT 311

  Fly   316 SSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLD 380
            ||.:.|.:|.||.:||||.|::.|::|.:...... ||:....::||:.||:||||||.|...|.
Mouse   312 SSILSFTVYSLATHPDIQKKLQEEIDEALPNKAPP-TYDTVMAMEYLDMVLNETLRLYPITNRLQ 375

  Fly   381 RMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFG 445
            |:..|...:.|   ..|..|.:|||||..:||||..:|||.||:|||||.|.........:||||
Mouse   376 RVCKKDVEING---IYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYLPFG 437

  Fly   446 DGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKV 503
            :|||||||:||..|..::.|..:::||.|..|.:|..||....:..:..||. |.|||
Mouse   438 NGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLSRELLLQPVKP-IVLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	142/446 (32%)
Cyp3a16	NP_031846.2	CYP3A	67..493	CDD:410743	144/453 (32%)