DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	523	Identity:	160/523 - (30%)
Similarity:	265/523 - (50%)	Gaps:	53/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            |::|...::.||.:...:.|   ..||:.|||...|....|.:  |...|...|.....:.|:
Mouse    11 TWMLLATSLVLLYLYGTHSH---GIFKKLGIPGPKPLPFLGTI--LAYQKGFWECDIQCHKKY-- 68

  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNK------GIFYNEKDDPISAHLFNLDG 126
              ....|.:..:.|...:.|.::.|.:|:|: :|.|:|:      ||.  :|...||      :.
Mouse    69 --GKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFGPVGIL--KKAISIS------EN 123

  Fly   127 AQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTV----MHEKVPKNSVLEIRDLVARFTVDVI 187
            .:|:.:|..||.|||||::|.|:|    :.|:|..|    |.:.:.:.....::|:...:::|||
Mouse   124 EEWKRIRALLSPTFTSGRLKEMFP----IINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVI 184

  Fly   188 GTCAFGIQCNSLRDEKAEFLYFGKRSL-VDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYS 251
            ...:||:..:||.:.:..|:...|:.| .|......|:  :..:|.|......:..:...::..|
Mouse   185 TATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLS--VTLFPFLTPVFDALNVSLFPRDVIS 247

  Fly   252 RIVTETVAVRE---KEHIK-RNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGF 312
            ...|....::|   ||..| |.||:.::|..:|.|  |.|:.   :.|:..|::||:.:|..||:
Mouse   248 FFTTSVERMKENRMKEKEKQRVDFLQLMINSQNYK--TKESH---KALSDVEIVAQSVIFIFAGY 307

  Fly   313 ETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVP 377
            ||:||.:.||||.||.:||:|.|::.|::..: .:....||:....::||:.|::||||||.|..
Mouse   308 ETTSSALSFALYLLAIHPDVQKKLQDEIDAAL-PNKAPATYDTLLQMEYLDMVVNETLRLYPIAG 371

  Fly   378 NLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWL 442
            .|:|:......:.|   ..|..|..|:||:.|:|.||..:|||.||||||||.:.........:|
Mouse   372 RLERVCKTDVEING---LFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYL 433

  Fly   443 PFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKV---- 503
            |||.|||||||:||..:..::.|..:::||....|.:|..||... |..:|..::.:.|||
Mouse   434 PFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLS-KQGLLQPENPLLLKVVSRD 497

  Fly   504 ETV 506
            |||
Mouse   498 ETV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	145/479 (30%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	145/481 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710