Protein Alignment Cyp6a8 and Cyp3a13

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_031845.1
• Gene: Cyp3a13 / 13113
• MGIID: 88610
• Length: 503
• Species: Mus musculus
• Alignment Length: 523
• Identity: 160/523 - (30%)
• Similarity: 265/523 - (50%)
• Gaps: 53/523 - (10%)

  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            |::|...::.||.:...:.|   ..||:.|||...|....|.:  |...|...|.....:.|:
Mouse    11 TWMLLATSLVLLYLYGTHSH---GIFKKLGIPGPKPLPFLGTI--LAYQKGFWECDIQCHKKY-- 68

  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNK------GIFYNEKDDPISAHLFNLDG 126
              ....|.:..:.|...:.|.::.|.:|:|: :|.|:|:      ||.  :|...||      :.
Mouse    69 --GKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFGPVGIL--KKAISIS------EN 123

  Fly   127 AQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTV----MHEKVPKNSVLEIRDLVARFTVDVI 187
            .:|:.:|..||.|||||::|.|:|    :.|:|..|    |.:.:.:.....::|:...:::|||
Mouse   124 EEWKRIRALLSPTFTSGRLKEMFP----IINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVI 184

  Fly   188 GTCAFGIQCNSLRDEKAEFLYFGKRSL-VDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYS 251
            ...:||:..:||.:.:..|:...|:.| .|......|:  :..:|.|......:..:...::..|
Mouse   185 TATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLS--VTLFPFLTPVFDALNVSLFPRDVIS 247

  Fly   252 RIVTETVAVRE---KEHIK-RNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGF 312
            ...|....::|   ||..| |.||:.::|..:|.|  |.|:.   :.|:..|::||:.:|..||:
Mouse   248 FFTTSVERMKENRMKEKEKQRVDFLQLMINSQNYK--TKESH---KALSDVEIVAQSVIFIFAGY 307

  Fly   313 ETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVP 377
            ||:||.:.||||.||.:||:|.|::.|::..: .:....||:....::||:.|::||||||.|..
Mouse   308 ETTSSALSFALYLLAIHPDVQKKLQDEIDAAL-PNKAPATYDTLLQMEYLDMVVNETLRLYPIAG 371

  Fly   378 NLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWL 442
            .|:|:......:.|   ..|..|..|:||:.|:|.||..:|||.||||||||.:.........:|
Mouse   372 RLERVCKTDVEING---LFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYL 433

  Fly   443 PFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKV---- 503
            |||.|||||||:||..:..::.|..:::||....|.:|..||... |..:|..::.:.|||
Mouse   434 PFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLS-KQGLLQPENPLLLKVVSRD 497

  Fly   504 ETV 506
            |||
Mouse   498 ETV 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	138/445 (31%)
Cyp3a13	NP_031845.1	CYP3A	67..492	CDD:410743	139/452 (31%)