Protein Alignment Cyp6a8 and Cyp3a11

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_031844.1
• Gene: Cyp3a11 / 13112
• MGIID: 88609
• Length: 504
• Species: Mus musculus
• Alignment Length: 517
• Identity: 164/517 - (31%)
• Similarity: 267/517 - (51%)
• Gaps: 50/517 - (9%)

  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            |::|..::   |.:|..|..||...||::|||...|....|.:  |...|.:.:...:.|.|:.:
Mouse    11 TWVLLAIS---LVLLYRYGTRKHELFKKQGIPGPKPLPFLGTV--LNYYKGLWKFDMECYKKYGK 70

  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNK------GIFYN----EKDDPISAHLF 122
            :    .|.|..|:|...|.|.|..|.:|:|: ||.|:|:      ||...    .|||
Mouse    71 T----WGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVGIMSKAISISKDD------- 124

  Fly   123 NLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVI 187
                 :|:..|..||.||||||:|.|:|.:....:..:..:.:|..|...:.::|::..:::|||
Mouse   125 -----EWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVI 184

  Fly   188 GTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQ---EF 249
            .:.:||:..:||.:.:..|:...|:.|.......||...: .:|.|.....|:......:   ||
Mouse   185 TSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVV-LFPFLTPVYEMLNICMFPKDSIEF 248

  Fly   250 YSRIVTETVAVR---EKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAG 311
            :.:.|......|   :::|  |.||:.:::...|..:..:.:    :.|:..|:.||:.:|..||
Mouse   249 FKKFVDRMKESRLDSKQKH--RVDFLQLMMNSHNNSKDKVSH----KALSDMEITAQSIIFIFAG 307

  Fly   312 FETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIV 376
            :||:|||:.|.|:.||.:||||.|::.|::|.:...... ||:...:::||:.||:||||||.|.
Mouse   308 YETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPP-TYDTVMEMEYLDMVLNETLRLYPIA 371

  Fly   377 PNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAW 441
            ..|:|:..|...:.|   ..|..|.:|:|||.|:||||..:.||.||:|||||.|.........:
Mouse   372 NRLERVCKKDVELNG---VYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVY 433

  Fly   442 LPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKV 503
            ||||:|||||:|:||..|..::.|..:::||.|..|.:|..||... :..:|..:..|.|||
Mouse   434 LPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLS-RQGLLQPEKPIVLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	142/446 (32%)
Cyp3a11	NP_031844.1	CYP3A	67..493	CDD:410743	144/453 (32%)