Protein Alignment Cyp6a8 and CYP4F22

DIOPT Version :9

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 120/530 - (22%)
• Similarity: 237/530 - (44%)
• Gaps: 63/530 - (11%)

  Fly     3 LTYILFQVAVALLAIL-TYYIH-RKLTYF---KRRGIPFVAPHL------IRGNMEELQKTKNIH 56
            |.:.||::.:..|.:. ::||. |:|..|   .||.  ::..||      ..|..:|.:...|:|
Human    31 LLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRN--WLLGHLGMYLPNEAGLQDEKKVLDNMH 93

  Fly    57 EIFQDHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHL 121
            .:.           ..::|...   |...::..:..|.:|....:......:||......:...|
Human    94 HVL-----------LVWMGPVL---PLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGL 144

  Fly   122 FNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEK---VPKNSV--LEIRDLVAR 181
            ....|.:|...|..|:..|....:|    ..:.:.|:...:||.|   :.:.|.  |::.:.::.
Human   145 LLSKGDKWSRHRRLLTPAFHFDILK----PYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISL 205

  Fly   182 FTVDVIGTCAFGIQCNSLRDEKAEFL-YFGKRSLVDKRHGTLLNGFMR-SYPKLARKLGMVRTAP 244
            .|:|.:..|.|....| .:::.:::: ...:.|.:..|....|:.::. .|.:.|......:...
Human   206 MTLDSLQKCVFSYNSN-CQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACD 269

  Fly   245 HIQEFYSRIVTE-TVAVREK--------EHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEV 300
            .:..|.:.::.| ..|:|::        :..|..||:|:|:..::      |:|   :.|:.|::
Human   270 MVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD------EDG---KELSDEDI 325

  Fly   301 LAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHD-QNFTYECTKDLKYLNQ 364
            .|:|..|...|.:|:||.:.:.|:.|||.|:.|:|.|.|::||::..: :...::....|.:...
Human   326 RAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTM 390

  Fly   365 VLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFS 429
            .:.|:||.|..|..:.|...:...:|  ...:|..|...::.....||:|:::|:...:.|.||.
Human   391 CIKESLRQYPPVTLVSRQCTEDIKLP--DGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFD 453

  Fly   430 PEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLG 494
            |:....|..:|::||..|||||||..|...:.|:.:||.:..|:.|. .:|..  |......:|.
Human   454 PDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSV-DRTRK--VRRKPELILR 515

  Fly   495 VKDGIYLKVE 504
            .::|::||||
Human   516 TENGLWLKVE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	106/486 (22%)
CYP4F22	NP_775754.2	p450	60..524	CDD:278495	108/498 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900