Protein Alignment Cyp6a8 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 118/486 - (24%)
• Similarity: 216/486 - (44%)
• Gaps: 47/486 - (9%)

  Fly     6 ILFQVAVALLA--ILTYYIHRKLTYFKR-RGIPFVAPHLIRGNMEELQKTKNI-HEIFQDHYNKF 66
            :|...:..|||  :...::||..:.::. .|.|  .|..:.|::....|...: ..:.||.:..:
Human     5 LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPP--RPSFLLGHLPCFWKKDEVGGRVLQDVFLDW 67

  Fly    67 RESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLF------NLD 125
            .:...|.|....|...:..|...|..|:.|:....|..:|  .|..........||      ..:
Human    68 AKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSK--MYRALQTVFGERLFGQGLVSECN 130

  Fly   126 GAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTC 190
            ..:|...|..:...|:...:..:..|....|.:.:.::..|....:.:.::|::....:|::...
Human   131 YERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKA 195

  Fly   191 AFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKL-GMVRTAPHIQEF--YSR 252
            |||::.:.|         .|.:..:.:....:|.|...|...||:.| |..:....::|.  :.|
Human   196 AFGMETSML---------LGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLR 251

  Fly   253 IVTETVAVREKEHIKRNDFM--DMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFV-FFIAGFET 314
            .|......|.:|.:||.:.:  |:|.::...:|          |...:|.|...|| |||||.||
Human   252 QVGRDWVQRRREALKRGEEVPADILTQILKAEE----------GAQDDEGLLDNFVTFFIAGHET 306

  Fly   315 SSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNL 379
            |::.:.|.:.||::.|:|..:::|||:|||.. .:...:|....|:||:|||.|:||||......
Human   307 SANHLAFTVMELSRQPEIVARLQAEVDEVIGS-KRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370

  Fly   380 DRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIY-PEPFEFRPERFSPEESAGRPSVAWLP 443
            .|:..:..::.|    |...|.:.::.|:.:......| .:|..|.|:||.|  .|.:|...:.|
Human   371 FRLLEEETLIDG----VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFP 429

  Fly   444 FGDGPRNCIGLRFGQMQARIGLALLIRNFKF 474
            |..|.|:|||.:|.||:.::.:|.|::..:|
Human   430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	105/418 (25%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	107/428 (25%)