DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	530	Identity:	143/530 - (26%)
Similarity:	231/530 - (43%)	Gaps:	74/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AVALLAILTYYIHRKLTYFKRRGIPFVA-PHLIRGNMEELQKTKNIHEIFQD---HYNKFRESKA 71
            |..|::|....:.....:.:.|.||.|| .:.:.|:  .|....|..|.||.   :..:||.  .
Mouse    27 ATILISIFPMLVSYARKWQQMRSIPSVARAYPLVGH--ALYMKPNNAEFFQQLIYYTEEFRH--L 87

  Fly    72 PFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWRLLRNKL 136
            |.:..:....|...:...|..:.||..  |...:|...|......:...|....|::||..|..|
Mouse    88 PIIKLWIGPVPLVALYKAENVEVILTS--SKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRRKML 150

  Fly   137 SSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGIQCNSLRD 201
            :.||..    .:....:.|.||...::..|:.|:...|..:.....|:     ||..|.|
Mouse   151 TPTFHF----TILENFLDVMNEQANILVNKLEKHVNQEAFNCFFYITL-----CALDIIC----- 201

  Fly   202 EKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGM------------------VRTAPHIQE 248
            |.|.....|.:|..|..:   :....|....:.|::.|                  .|....:..
Mouse   202 ETAMGKNIGAQSNNDSEY---VRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHT 263

  Fly   249 FYSRIVTETVAVREKEH-------------IKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEV 300
            |.:.::.|.|..|:.|.             .||..|:|:|:      .:|.|.|:   .|:.|::
Mouse   264 FTNNVIAERVKERKAEEDWTGAGRGPIPSKNKRKAFLDLLL------SVTDEEGN---RLSQEDI 319

  Fly   301 LAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQV 365
            ..:...|...|.:|:::.:.::||.|..||::|.||..|::||..:..:..|.|..|.||||:.|
Mouse   320 REEVDTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKKLKYLDCV 384

  Fly   366 LDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSP 430
            :.||||::..||...|..::...|.|:.  |.:..:::||| .|:|.||..:|:|.|||||||.|
Mouse   385 IKETLRVFPSVPLFARSLSEDCEVGGYK--VTKGTEAIIIP-YALHRDPRYFPDPEEFRPERFFP 446

  Fly   431 EESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPN-PLVYDPKSFVLG 494
            |.|.||...|::||..|||||||.:|..|:.:..||.::|.|...:..|... .|..|   .:|.
Mouse   447 ENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGD---LILR 508

  Fly   495 VKDGIYLKVE 504
            ..:||::|::
Mouse   509 PNNGIWIKLK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	134/498 (27%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	137/503 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810