Protein Alignment Cyp6a8 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 514
• Identity: 141/514 - (27%)
• Similarity: 257/514 - (50%)
• Gaps: 53/514 - (10%)

  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            |::|...::....|...|.|   ..||:.|||...|..:.|.:  ......:.:..:|.|.|:
Mouse    11 TWVLLVTSLVFFYIYGTYSH---GLFKKLGIPGPKPLPLFGTI--FNYFDGMWKFDEDCYKKY-- 68

  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNK----GIFYNEKDDPISAHLFNLDGAQ 128
              ....||:....|...::|.|:.|.:|:|: :|.|:|:    .:.:.:|...||      :..:
Mouse    69 --GKIWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNRPTLGPVGFLKKSITIS------EDEE 125

  Fly   129 WRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFG 193
            |:.||..||.||||||:|.|:|.:....:..:..:..:..|...:.::|:...:::|||...:||
Mouse   126 WKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSMDVITGTSFG 190

  Fly   194 IQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRS---YPKLARKLGMVRTA--PH-----IQE 248
            :..:||.:.:..|:...|:.|..|    :.:.|:.|   :|.|.....|:..:  |.     .::
Mouse   191 VNIDSLNNPQNPFVQKTKKILKFK----IFDPFLLSTILFPFLTPIYEMLNLSIFPRDSMNFFKK 251

  Fly   249 FYSRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFE 313
            |..|:..|.:|.::|..:   ||:.:::..:|.|....:     :.|:..|:.|||.:|...|::
Mouse   252 FVKRMKKERLASKQKNRV---DFLQLMMNTQNSKGQESQ-----KALSDLEMAAQAVIFIFGGYD 308

  Fly   314 TSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPN 378
            .:|:::...:||||.:||:|.|::.|::..: .:....||:...|::||:.|::|:||||.....
Mouse   309 ATSTSISLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMDMEYLDMVVNESLRLYPTAIR 372

  Fly   379 LDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLP 443
            |:|::.|...:.|   ..|..|..|:||...:|.:|..:|||.||.|.|||.|.........::|
Mouse   373 LERVSKKDVEING---VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYIYMP 434

  Fly   444 FGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPL------VYDP-KSFVLGV 495
            ||:|||||:.:||..:..::.:..:::||....|.:|..||      |:.| |..:|.|
Mouse   435 FGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKISREPVFQPEKPIILKV 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	126/448 (28%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	125/450 (28%)