DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and Cyp4a32

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001093651.1	Gene:	Cyp4a32 / 100040843	MGIID:	3717148	Length:	509	Species:	Mus musculus

Alignment Length:	523	Identity:	134/523 - (25%)
Similarity:	238/523 - (45%)	Gaps:	63/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QVA--VALLAILT----YYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQ--DHYNK 65
            |||  :.||.:|.    :|:|||......:..|....|...|: |:.:..:.:.|:..  :|:
Mouse    20 QVASVLGLLLLLVKAVQFYLHRKWLLKALQQFPSPPFHWFFGH-EQFKGEQELKEVVSCIEHF-- 81

  Fly    66 FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWR 130
                .:.|..:|:..:....|.|.:..|.||.:  |:....|| |......|...|..|:|..|.
Mouse    82 ----PSAFPCWFWGSNAYLTVYDPDYMKVILGR--SDPKANGI-YRLLAPWIGYGLLLLNGQPWF 139

  Fly   131 LLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEK----VPKNSVLEIRDLVARFTVDVIGTCA 191
            ..|..|:..|   ...::.|.|.::|:. :.:|.:|    ..::|.:||...::..|:|.:..||
Mouse   140 QHRRMLTPAF---HYDILKPYVKNMADS-IRLMLDKWERLAGQDSSIEIFQHISLMTLDTVMKCA 200

  Fly   192 FGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGF--------MRSYPKLAR---KLGMVRTAPH 245
            |..:.:...|...:........|.:..|..:.|.|        :.|..:||:   :|....|...
Mouse   201 FSHKGSVQVDGNYKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAKQACQLAHDHTDGV 265

  Fly   246 IQEFYSRIVTETVAVREKEHIK---RNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVF 307
            |:....::..|    .|.|:||   |.||:|:|:..:      :||||   .::.:::.|:...|
Mouse   266 IKMRKDQLQDE----GELENIKKKRRLDFLDILLFAR------MENGD---SMSDKDLRAEVDTF 317

  Fly   308 FIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRL 372
            ...|.:|::|.:.:..|.||.:|:.|.:.|.||:.::.. ..:.|::....:.|....:.|.|||
Mouse   318 MFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGD-GSSITWDHLDQIPYTTMCIKEALRL 381

  Fly   373 YTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRP 437
            |..||.:.|..:.....|...:  :..|..|.:....:||:|.::|.|..|.|.||:|:  :.|.
Mouse   382 YPPVPGIVRELSTSVTFPDGRS--LPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPD--SPRH 442

  Fly   438 SVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK-FSTCSKTPNPLVYDPKSFVLGVKDGIYL 501
            |.::|||..|.|||||.:|...:.::.:||.:.:|: ....::.|.||.    ..||..|:||||
Mouse   443 SHSFLPFSGGARNCIGKQFAMSELKVIVALTLLHFELLPDPTRVPEPLA----RIVLKSKNGIYL 503

  Fly   502 KVE 504
            .::
Mouse   504 HLK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	123/484 (25%)
Cyp4a32	NP_001093651.1	p450	52..503	CDD:278495	122/486 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900