DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a21 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	555	Identity:	139/555 - (25%)
Similarity:	235/555 - (42%)	Gaps:	121/555 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLALVG--YLL---MKW---------------RSTMRHW----QDLGIPCEEPHILMGSMKGVRT 51
            ||.|||  :||   :.|               :...|:|    |.:..|.||         |:|.
Human    21 LLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEE---------GMRV 76

  Fly    52 ARSFNEIWTSYYNKFR-GSGPFAGFYWFRRPAVF--VLETSLAKQILIKEFNKFTDRGFFHNPED 113
               ..::..:|...|: ..||.:.......|.:.  |:..|.|  |..|:       .||::..:
Human    77 ---LTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAA--IAPKD-------KFFYSFLE 129

  Fly   114 DPLSGQLFLLDGQKWRTMRNKLSSTFTSGKMK-YMFPTVVKVANEFTDVF---GQNVAK--SPVV 172
            ..|...|.|..|.||...|..|:..|....:| ||     |:.||..::.   .|.:|.  |..:
Human   130 PWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYM-----KIFNESVNIMHAKWQLLASEGSACL 189

  Fly   173 EVRELLARFTTDVIGTCAFGIECSSLKDPD---AEFREMGRRSLTEQR-------------LGPV 221
            ::.|.::..|.|.:..|.|..:....:.|.   |...|:.  :|..:|             |.|.
Human   190 DMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELS--ALVSKRHHEILLHIDFLYYLTPD 252

  Fly   222 GIGFVNSFPNLARRLHMKMTAEPIERFFMRIVRETVAFREQNNIRRNDFMDQLID------LKNK 280
            |    ..|....|.:|         .|...:::|          ||.....|.:|      .|:|
Human   253 G----QRFRRACRLVH---------DFTDAVIQE----------RRRTLPSQGVDDFLQAKAKSK 294

  Fly   281 P------LMVSQSGESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQ 339
            .      |::|:..:...|:.|:|.|:|..|...|.:|:::.:.:.||.||::.:.|.|.|:|.|
Human   295 TLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQ 359

  Fly   340 EVI-EKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKGMPVL 402
            |:: ::...|:.::.:..|.:|...:.|:|||:..:||::|...:|..:| |.   ||.||:..|
Human   360 ELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGR---VIPKGIICL 421

  Fly   403 IPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLI 467
            |.....|.:..::.:|..::|..|.||.:|||..:.::||..|||||||..|...:.::.|||.:
Human   422 ISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486

  Fly   468 KDFKFSVCEKTTIPMTYNKEMFLIASNSGIYLKAE 502
              .:|.|....|.|.  .|...::.:..|::|:.|
Human   487 --LRFRVLPDHTEPR--RKPELVLRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	126/502 (25%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	8/35 (23%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	129/520 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810