DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and CYP735A2

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_176882.1	Gene:	CYP735A2 / 843031	AraportID:	AT1G67110	Length:	512	Species:	Arabidopsis thaliana

Alignment Length:	537	Identity:	132/537 - (24%)
Similarity:	227/537 - (42%)	Gaps:	84/537 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVLLTALLALVGYLLMKW------------RSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNE 57
            |::|..:|.:|..|:::.            |...:..:..||...:|.:|.|::..:....|.:.
plant     4 TLVLKYVLVIVMTLILRVLYDSICCYFLTPRRIKKFMERQGITGPKPRLLTGNIIDISKMLSHSA 68

  Fly    58 --------------------IWTSYYNK----FRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE 98
                                .|:..|.|    :.|:          .|.:.:.||.:.|::|.|.
plant    69 SNDCSSIHHNIVPRLLPHYVSWSKQYGKRFIMWNGT----------EPRLCLTETEMIKELLTKH 123

  Fly    99 FNKFTDRGFFHNPEDDPLSGQ-LFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVF 162
             |..|.:.:..........|: |.:.:|:.|...|:..:..||..::|.....:|:......:..
plant   124 -NPVTGKSWLQQQGTKGFIGRGLLMANGEAWHHQRHMAAPAFTRDRLKGYAKHMVECTKMMAERL 187

  Fly   163 GQNVAKSPVVEVRELLARFTTDVIGTCAFGIECSSLKDPDAEFREMGR--RSLTEQRLGPVGIGF 225
            .:.|.:.  ||:.|.:.|.|.|:|....||..|...|:..:....:.|  ...|.....| |..|
plant   188 RKEVGEE--VEIGEEMRRLTADIISRTEFGSSCDKGKELFSLLTVLQRLCAQATRHLCFP-GSRF 249

  Fly   226 VNSFPNLARRLHMKMTAEPIERFFMRIV---RETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQS 287
            :.|..|    ..:|.....:||..|.|:   :::|...     |.:.:.|.|:.|    |:....
plant   250 LPSKYN----REIKSLKTEVERLLMEIIDSRKDSVEIG-----RSSSYGDDLLGL----LLNQMD 301

  Fly   288 GESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYE 352
            ....||.::.|..:...||..|.||:|..:.:.|..||.|...|:.||.|.::|..: :|..:.|
plant   302 SNKNNLNVQMIMDECKTFFFTGHETTSLLLTWTLMLLAHNPTWQDNVRDEVRQVCGQ-DGVPSVE 365

  Fly   353 SMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYA- 416
            .:..|..|::|::|:||||....:|.|...||.::   ...:|.||:.:.||..|:|...:|:.
plant   366 QLSSLTSLNKVINESLRLYPPATLLPRMAFEDIKL---GDLIIPKGLSIWIPVLAIHHSNELWGE 427

  Fly   417 NPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEK---- 477
            :.|.|||:.|:....  ..|..::||..|||||||..|..|:|:|.||:|:..|.|::.|.
plant   428 DANEFNPERFTTRSF--ASSRHFMPFAAGPRNCIGQTFAMMEAKIILAMLVSKFSFAISENYRHA 490

  Fly   478 ----TTIPMTYNKEMFL 490
                .||...|..::.|
plant   491 PIVVLTIKPKYGVQLVL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	124/495 (25%)
CYP735A2	NP_176882.1	PLN02290	2..511	CDD:215164	132/537 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000