DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a21 and CYP711A1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_565617.2	Gene:	CYP711A1 / 817157	AraportID:	AT2G26170	Length:	522	Species:	Arabidopsis thaliana

Alignment Length:	543	Identity:	128/543 - (23%)
Similarity:	237/543 - (43%)	Gaps:	99/543 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRGSGP 71
            |..|.:.:|.||   :|.:   |....:|......|:|.:.  ..|:...::::....::   ||
plant    25 LTFAAVVIVIYL---YRPS---WSVCNVPGPTAMPLVGHLP--LMAKYGPDVFSVLAKQY---GP 78

  Fly    72 FAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQ------LFLLDGQKWRT 130
            ...|...|:|.:.:.|..|.:::.||:|....:|..     ..|:|..      ||....::|..
plant    79 IFRFQMGRQPLIIIAEAELCREVGIKKFKDLPNRSI-----PSPISASPLHKKGLFFTRDKRWSK 138

  Fly   131 MRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSP-VVEVRELLARFTTDVIGTCAFGIE 194
            |||.:.|.:....:..:.||:    :.|......|:...| .:....|..:.|||:||..|||:
plant   139 MRNTILSLYQPSHLTSLIPTM----HSFITSATHNLDSKPRDIVFSNLFLKLTTDIIGQAAFGV- 198

  Fly   195 CSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHMKMTA--------------EPI 245
                     :|...|::.:.:..:    ..|:|.......:|.|.::.              ||.
plant   199 ---------DFGLSGKKPIKDVEV----TDFINQHVYSTTQLKMDLSGSLSIILGLLIPILQEPF 250

  Fly   246 ERFFMRIVRETVAFR-EQNNIRRNDFMDQLI---------DLKNKPLMVSQSGES----VNL-TI 295
            .:...|| ..|:.:| |:.|.|.:..:::::         |.|:...::.::.||    .|: |.
plant   251 RQVLKRI-PGTMDWRVEKTNARLSGQLNEIVSKRAKEAETDSKDFLSLILKARESDPFAKNIFTS 314

  Fly   296 EEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLV-- 358
            :.|:|..:....||..|::.|:...||.::.:.|::.|       ::::.:|..|    :||:
plant   315 DYISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKR-------LLQEIDGFGN----RDLIPT 368

  Fly   359 ---------YLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKL 414
                     |||||:.|.:|.|.|.|::.||..::.|:.|   |::.||..|.:..|.:.:|.|.
plant   369 AHDLQHKFPYLDQVIKEAMRFYMVSPLVARETAKEVEIGG---YLLPKGTWVWLALGVLAKDPKN 430

  Fly   415 YANPNTFNPDNFSP--ERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEK 477
            :..|..|.|:.|.|  |..|.|....::|||.|||.|:|.||...:.::.|..|.:::.|....:
plant   431 FPEPEKFKPERFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLE 495

  Fly   478 TTIPMTYNKEMFLIASNSGIYLK 500
            ..||:..:..:.|...| |:.|:
plant   496 MEIPLQLDYGIILSFKN-GVKLR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	120/512 (23%)
CYP711A1	NP_565617.2	cytochrome_P450	75..515	CDD:425388	116/481 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760