DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp20a1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_084289.1	Gene:	Cyp20a1 / 77951	MGIID:	1925201	Length:	462	Species:	Mus musculus

Alignment Length:	492	Identity:	115/492 - (23%)
Similarity:	207/492 - (42%)	Gaps:	71/492 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTALLALVGYLLMKWRSTMRHWQDLGI----PCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRG 68
            :|.||||||.:|..:.::.   |..||    |.||..   |::..:..:.|.:|...:.:.::
Mouse     9 VTFLLALVGAVLYLYPASR---QASGIPGLTPTEEKD---GNLPDIVNSGSLHEFLVNLHERY-- 65

  Fly    69 SGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQLFLLDGQK------ 127
             ||...| ||.|..|..|.|:   .:|.:.||.        |...||....|..|.|.:
Mouse    66 -GPVVSF-WFGRRLVVSLGTT---DVLKQHFNP--------NKTSDPFETMLKSLLGYQSGGGSA 117

  Fly   128 -WRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGTCAF 191
             ...:|.||.....:..:...||.:::::.|..|.: .:..::..:.:.:.:..|....:.....
Mouse   118 GEDHVRRKLYGDAVTASLHSNFPLLLQLSEELLDKW-LSYPETQHIPLSQHMLGFALKFVTRMVL 181

  Fly   192 GIECSSLKDPD--AEFREMGRRSLTEQRLGPVGIGFVNSF--PNLARRLHMKMTAEPIERFFMRI 252
            |   |:.:|..  ..|:::.....:|     :|.||::..  .|..|:...:.....:|....:|
Mouse   182 G---STFEDEQEVIRFQKIHGTVWSE-----IGKGFLDGSLDKNTTRKKQYQEALMQLESTLKKI 238

  Fly   253 VRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFFAAGFETSSTTM 317
            ::|    |:..|.|::.|:|.|...|              |..::|.....||..|....::...
Mouse   239 IKE----RKGGNFRQHTFIDSLTQGK--------------LNEQQILEDCVVFSLASCIITARLC 285

  Fly   318 GFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECL 382
            .:.::.|....::|.::.||..:|:.:  |.:..|.::.|.|..||:.||:|...:.||..|  |
Mouse   286 TWTIHFLTTTGEVQKKLCKEIDQVLGE--GPITSEKIEQLSYCQQVLFETVRTAKLTPVSAR--L 346

  Fly   383 EDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPR 447
            :|.|....| :||.|...||...|.:.:|...:..|:.|:||.|:.|.|.:..|.  |.| .|..
Mouse   347 QDIEGKVGP-FVIPKETLVLYALGVVLQDPSTWPLPHRFDPDRFADEPVMKVFSS--LGF-SGTW 407

  Fly   448 NCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTY 484
            .|..:||..|...:.:::|:|..:....::....|.|
Mouse   408 ECPELRFAYMVTAVLVSVLLKRLRLLAVDRQVFEMKY 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	104/461 (23%)
Cyp20a1	NP_084289.1	p450	43..446	CDD:299894	101/452 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7447
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950