DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	549	Identity:	129/549 - (23%)
Similarity:	231/549 - (42%)	Gaps:	105/549 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLTALLALVGYLL----------MKWR----STMRHW--QDLGI--PCEEPHILMGSMKGVRTA 52
            :||.....|:.|:|          ::.|    ...|:|  ..||:  ..||..:.:.|:  |||.
Mouse    22 LLLAGASCLLAYILTPIYGVFENSLRLRCFPQPPKRNWILGHLGLIQSSEEGLLYIQSL--VRTF 84

  Fly    53 RSFNEIWTSYYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE---FNKFTDRGFFHNPEDD 114
            |.....|.         ||.........|| |:....||..::..:   |.:|.          .
Mouse    85 RDACCWWV---------GPLHPVIRIFHPA-FIKPVVLAPALVAPKDTVFYRFL----------K 129

  Fly   115 PLSGQ-LFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVF---GQNVAK--SPVVE 173
            |..|. |.:..|.||...|..|:..|....:|    ..|||.|:.|::.   .|.:|.  |..:.
Mouse   130 PWLGDGLLMSTGDKWSRHRRMLTPAFHFNILK----PYVKVFNDSTNIMHAKWQRLASKGSAYLN 190

  Fly   174 VRELLARFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHM 238
            :.|.::..|.|.:..|.|..: |:.::..:|:                 |..:.....|..|.|.
Mouse   191 MFEHISLMTLDSLQKCVFSFD-SNCQEKPSEY-----------------ITAILELSTLVARRHQ 237

  Fly   239 KMTAEPIERFFMRIVRETVAFREQNNI-----------RRNDFMDQ----LIDLKNKP------- 281
            ::... ::.|:. :..:.:.||:...:           ||...:||    ::..|.|.
Mouse   238 RLLLH-VDLFYY-LTHDGMRFRKACRLVHDFTDAVIRERRRTLLDQGGVDVLKAKAKAKTLDFID 300

  Fly   282 -LMVSQSGESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVI-EK 344
             |::|:......|:.|:|.|:|..|...|.:|:::.:.:.||.||::.:.|.|.|:|.:|:: ::
Mouse   301 VLLLSKDEHGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDR 365

  Fly   345 CNGELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKGMPVLIPCGAM 408
            ...|:.::.:..|.:|...:.|:|||:..:..::|.|.:|..:| |.   ||.||:...|.....
Mouse   366 EPEEIEWDDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGR---VIPKGVISRISIFGT 427

  Fly   409 HRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFS 473
            |.:..::.:|..::|..|..:.||.|..:.::||..|||||||..|...:.::.|||.:  .:|.
Mouse   428 HHNPAVWPDPEVYDPFRFDADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTL--LRFR 490

  Fly   474 VCEKTTIPMTYNKEMFLIASNSGIYLKAE 502
            |......|.  .|...::.:..|::||.|
Mouse   491 VLPDDKEPR--RKPELILRAEGGLWLKVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	116/497 (23%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	121/516 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900