DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a21 and TBXAS1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001159725.2	Gene:	TBXAS1 / 6916	HGNCID:	11609	Length:	579	Species:	Homo sapiens

Alignment Length:	588	Identity:	157/588 - (26%)
Similarity:	264/588 - (44%)	Gaps:	109/588 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVGTVLLTALLALVGYLLMKWRST--MRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYY 63
            :.|...::|..|::....|:||.||  ....:.||:...:|...:|::...|..     .|.|..
Human     9 LEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQG-----FWESQM 68

  Fly    64 NKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDR---GFFHNPEDDPLSGQLFLLDG 125
            ...:..||..|:|..||..:.:.|..:.||:|::.|:.||:|   |.......|.:   |||.|
Human    69 ELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSV---LFLRD- 129

  Fly   126 QKWRTMRNKLSSTFTSGKMKYMF----------------------PT------------------ 150
            ::|..:|..|.|.|:..|:..:.                      ||
Human   130 KRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLP 194

  Fly   151 --VVKVANEFTDVFGQNVAK----SPVVEVRELLARFTTDVIGTCAFGIECSSLKDPDAEFREMG 209
              :|.:.::..|:...::.:    ....:::.....:||||:.:.|||....|.:.|:..|.:..
Human   195 FCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHC 259

  Fly   210 RRSLTEQRLGPVGIGFVNSFPN----LARRLHMKMTAEPIERFFMRIVRETVAFREQN--NIRRN 268
            :|........|: :..:.|||:    |||.|..| ..:.:..||.:::|..:|.|:|.  ..||.
Human   260 KRFFEFCIPRPI-LVLLLSFPSIMVPLARILPNK-NRDELNGFFNKLIRNVIALRDQQAAEERRR 322

  Fly   269 DFMDQLIDLKN--KPLMV----------SQSGESVN-------------LTIEEIAAQAFVFFAA 308
            ||:..::|.::  .|:.|          |.:|...|             ||::||..|||:|..|
Human   323 DFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIA 387

  Fly   309 GFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEK------CNGELNYESMKDLVYLDQVVSET 367
            |:|..:.|:.||.|.||.|.|.|.::.:|.....||      |:.|      :.|.|||.|::||
Human   388 GYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLE------EGLPYLDMVIAET 446

  Fly   368 LRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVK 432
            ||:|.......||..:|.||.|..   |..|..:.:..||:|.|.:.:.:|.||||:.|:.|..:
Human   447 LRMYPPAFRFTREAAQDCEVLGQR---IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ 508

  Fly   433 ERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNSGI 497
            :.....:||||.|||:|:|:|.|.::.::.|..::..|:|..|.:|.:|:....:..|...| |:
Human   509 QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKN-GV 572

  Fly   498 YLK 500
            |:|
Human   573 YIK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	145/549 (26%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	147/550 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820