DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a21 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	541	Identity:	134/541 - (24%)
Similarity:	235/541 - (43%)	Gaps:	90/541 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VGTVLLTALLALVGYLLMKWRSTMRH-----------------WQDLGI--PCEEPHILMGSMKG 48
            ||:.||..:||        |.....:                 |..||:  |.||     |....
Human    26 VGSWLLARILA--------WTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEE-----GLKNS 77

  Fly    49 VRTARSFNEIWTSYYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE--FNKFTDRGFFHNP 111
            .:.:.::::.:|.:.      ||...|.....|......|:.:..|..|:  |.:|.
Human    78 TQMSATYSQGFTVWL------GPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFL-------- 128

  Fly   112 EDDPLSGQLFLLD-GQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAK--SPVVE 173
              .|..|:..||. |.||...|..|:..|....:|.......|.||...|.: |::|.  |..::
Human   129 --KPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKW-QHLASEGSSRLD 190

  Fly   174 VRELLARFTTDVIGTCAFGIECSSLKDPD---AEFREMGRRSLTEQRLGPV--GIGFVNSFPNLA 233
            :.|.::..|.|.:..|.|..:....:.|.   |...|:.  :|.|:|...:  .:.|:....:..
Human   191 MFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELS--ALVEKRSQHILQHMDFLYYLSHDG 253

  Fly   234 RRLHMKMTAEPIERFFMRIVRE---TVA-------FREQNNIRRNDFMDQLIDLKNKPLMVSQSG 288
            ||.|  .....:..|...::||   |:.       |:::...:..||:|        .|::|:..
Human   254 RRFH--RACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID--------VLLLSKDE 308

  Fly   289 ESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVI-EKCNGELNYE 352
            :...|:.|:|.|:|..|...|.:|:::.:.:.||.||::.:.|.|.|:|.||:: ::...|:.::
Human   309 DGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWD 373

  Fly   353 SMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKGMPVLIPCGAMHRDEKLYA 416
            .:..|.:|...|.|:|||:...|.::|.|.:|..:| |.   ||.||:..||....:|.:..::.
Human   374 DLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGR---VIPKGITCLIDIIGVHHNPTVWP 435

  Fly   417 NPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIP 481
            :|..::|..|.||..|.|..:.::||..|||||||..|...:.::.|||::..|:|  ....|.|
Human   436 DPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF--LPDHTEP 498

  Fly   482 MTYNKEMFLIASNSGIYLKAE 502
            .  .|...::.:..|::|:.|
Human   499 R--RKLELIMRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	122/485 (25%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	124/494 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810