DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	545	Identity:	123/545 - (22%)
Similarity:	239/545 - (43%)	Gaps:	95/545 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVLLTALLALVGYLLMKWRSTMRHWQDL-GIPCEEP--HILMGSMKGVR-TARSFNEIWTSYYNK 65
            |:||.....::..:|::..:..|:::.| |.| :.|  :.|||.:..|. |.:...|:     .:
Mouse    21 TLLLLGASWILARILIQIYAAYRNYRHLHGFP-QPPKRNWLMGHVGMVTPTEQGLKEL-----TR 79

  Fly    66 FRGSGPFAGFYWF--RRPAVFVLETSLAKQIL-------IKEFNKFTDRGFFHNPEDDPLSGQLF 121
            ..|:.|.....|.  ..|.:.:..:.:.:.||       :|:.       .|::.....|...|.
Mouse    80 LVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDV-------IFYSILKPWLGDGLL 137

  Fly   122 LLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAK-----SPVVEVRELLARF 181
            :..|.||...|..|:..|....:|    ..||:.|:.|::......:     |..:::.|.::..
Mouse   138 VSAGDKWSRHRRMLTPAFHFNILK----PYVKIFNDSTNIMHAKWQRLISDGSARLDMFEHVSLM 198

  Fly   182 TTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHMKMTAEPIE 246
            |.|.:..|.|..: |:.::..:|:                 |..:.....|..:.|.    :|:
Mouse   199 TLDSLQKCVFSFD-SNCQEKSSEY-----------------IAAILELSALVAKRHQ----QPL- 240

  Fly   247 RFFM----RIVRETVAFREQNNI-----------RRNDFMDQLID--LKNKP----------LMV 284
             .||    .:..:.:.||:..|:           |.....||.:|  ||:|.          |::
Mouse   241 -MFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLLL 304

  Fly   285 SQSGESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIE-KCNGE 348
            |:..:...|:.|:|.|:|..|...|.:|:::.:.:.||.||::.:.|.|.|:|.||::. :...|
Mouse   305 SKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEE 369

  Fly   349 LNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKGMPVLIPCGAMHRDE 412
            :.::.:..|.:|...:.|:|||:..:.|::|.|.:|..:| |.   .|.||:..||....:|.:.
Mouse   370 IEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGR---TIPKGIICLISIFGIHHNP 431

  Fly   413 KLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEK 477
            .::.:|..::|..|.||.:|:...:.::||..|||||||..|...:.::.|||.:..|:....:|
Mouse   432 SVWPDPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDK 496

  Fly   478 TTIPMTYNKEMFLIASNSGIYLKAE 502
            .    ...:...::.:..|::|:.|
Mouse   497 E----PRRQPELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	114/509 (22%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	113/506 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900