Protein Alignment Cyp6a21 and CYP20A1

DIOPT Version :9

• Sequence 1: NP_611003.2
• Gene: Cyp6a21 / 36665
• FlyBaseID: FBgn0033981
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001358624.1
• Gene: CYP20A1 / 57404
• HGNCID: 20576
• Length: 470
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 119/507 - (23%)
• Similarity: 209/507 - (41%)
• Gaps: 77/507 - (15%)

  Fly     8 LTALLALVGYLLMKWRSTMRHWQDLGI----PCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRG 68
            :|.||||||.:|..:.::.   |..||    |.||..   |::..:..:.|.:|...:.:.::
Human     9 VTFLLALVGAVLYLYPASR---QAAGIPGITPTEEKD---GNLPDIVNSGSLHEFLVNLHERY-- 65

  Fly    69 SGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQL-FLLDGQKW---- 128
             ||...| ||.|..|..|.|   ..:|.:..|.        |...||....| .||..|..
Human    66 -GPVVSF-WFGRRLVVSLGT---VDVLKQHINP--------NKTSDPFETMLKSLLRYQSGGGSV 117

  Fly   129 --RTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGTCAF 191
              ..||.||.....:..:|..|..::|::.|..|.: .:..::..|.:.:.:..|....:.....
Human   118 SENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKW-LSYPETQHVPLSQHMLGFAMKSVTQMVM 181

  Fly   192 GIECSSLKDPDAEFREMGRRSLT------EQRLGPVGIGFVNSF--PNLARRLHMKMTAEPIERF 248
            |   |:.:| |.|.....:...|      .|....:|.||::..  .|:.|:...:.....:|..
Human   182 G---STFED-DQEVIRFQKNHGTLCIFTYFQVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESV 242

  Fly   249 FMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFFAAGFETS 313
            ...|::|    |:..|..::.|:|.|:              ..||..::|...:.:|..|....:
Human   243 LRNIIKE----RKGRNFSQHIFIDSLV--------------QGNLNDQQILEDSMIFSLASCIIT 289

  Fly   314 STTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLN 378
            :....:|:..|..::::|.::.:|..:|..  ||.:..|.::.|.|...|:.||:|...:.||..
Human   290 AKLCTWAICFLTTSEEVQKKLYEEINQVFG--NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSA 352

  Fly   379 RECLEDYEVPGH-PKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPF 442
            :  |:|.|  |. .:::|.:...||...|.:.:|...:.:|:.|:||.|..|.|.:..|.  |.|
Human   353 Q--LQDIE--GKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSS--LGF 411

  Fly   443 GDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASN 494
             .|.:.|..:||..|...:.|::|:|.......|...|...|.    |:.|:
Human   412 -SGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIETKYE----LVTSS 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	108/476 (23%)
CYP20A1	NP_001358624.1	p450	43..454	CDD:386267	103/461 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7447
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950