DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	506	Identity:	142/506 - (28%)
Similarity:	263/506 - (51%)	Gaps:	51/506 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVGT--VLLTALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSMKGVRTARSFNEIWTS 61
            :|:.|  :|:|:|:....|      .|..|  ::.||||..:|..|:|::     ...::.:|..
Mouse     7 LSIETWVLLVTSLVLFYIY------GTYSHGLFKKLGIPGPKPLPLLGTI-----FNYYDGMWKF 60

  Fly    62 YYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDRGFFHNPEDDP---LSGQLFL 122
            ..:.::..|...|||...:|.:.:::..:.|.:|:|| ::.||:|.||     .|   :...:.:
Mouse    61 DEDCYKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFF-----GPVGFMKKAITI 120

  Fly   123 LDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNV----AKSPVVEVRELLARFTT 183
            .:.::|:.:|..||.||||||:|.|||    :..::.|:..:|:    .|...:.::::...::.
Mouse   121 SEDEEWKRLRTLLSPTFTSGKLKEMFP----IMRQYGDILVRNLRREEEKGEPISMKDIFGAYSM 181

  Fly   184 DVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHM-------KMT 241
            |||...:||:...||.:|...|.:..::.|..:...|..:..: .||.|.....|       :.:
Mouse   182 DVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSII-LFPFLTPIYEMLNFSIFPRDS 245

  Fly   242 AEPIERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFF 306
            ....::|..|:.:|.:|..::|.:   ||:..:::.:|.....||..    |:..|:||||.:|.
Mouse   246 MNFFKKFVKRMKKERLASNQKNRV---DFLQLMMNTQNSKGQESQKA----LSDLEMAAQAVIFI 303

  Fly   307 AAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLY 371
            ..|::.:||::...:||||.:.|:|.:::.|....:.. ...:.|:::.|:.|||.||:|:||||
Mouse   304 FGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPN-KAPVTYDALMDMEYLDMVVNESLRLY 367

  Fly   372 TVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDS 436
            .:...|.|...:|.|:.|   ..|.||..|:||...:||:.:.:..|..|.|:.||.|.....|.
Mouse   368 PIAIRLERVSKKDVEING---VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDP 429

  Fly   437 VEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKE 487
            ..::|||:||||||||||..:..::.:..::::|....||:|.||:..::|
Mouse   430 YIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISRE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	131/468 (28%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	131/468 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720