DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	127/547 - (23%)
Similarity:	241/547 - (44%)	Gaps:	99/547 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVLLTALLALVGYLLMKWRSTMRHWQDL-GIPCEEP--HILMGSMKGVR-TARSFNEIWTSYYNK 65
            |:||.....::..:|.:..:..|:::.| |.| :.|  :.|||.:..|. |.:...|:     .:
  Rat    21 TLLLFGASWILAQILTQIYAAYRNFRRLRGFP-QPPKRNWLMGHVGMVTPTEQGLKEL-----TR 79

  Fly    66 FRGSGPFAGFYWF--RRPAVFVLETSLAKQIL-------IKEFNKFTDRGFFHNPEDDPLSGQLF 121
            ..|:.|.....|.  ..|.:.:..:.:.:.||       :|:.       .|:......|...|.
  Rat    80 LVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDV-------IFYTILKPWLGDGLL 137

  Fly   122 LLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAK-----SPVVEVRELLARF 181
            :..|.||...|..|:..|....:|    ..||:.|:.|::......:     |..:::.|.::..
  Rat   138 VSAGDKWSRHRRMLTPAFHFNILK----PYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEHVSLM 198

  Fly   182 TTDVIGTCAFGIECSSLKDPDAEF----REMGRRSLTEQR-------------LGPVGIGFVNSF 229
            |.|.:..|.|..: |:.::..:|:    .|:.  :|..:|             |.|.|:.| :..
  Rat   199 TLDSLQKCVFSFD-SNCQEKSSEYIAAILELS--ALVAKRHQQPLLFMDLLYNLTPDGMRF-HKA 259

  Fly   230 PNLARRLHMKMTAEPIERFFMRIVRETVAFREQNNIRRNDFMDQLID--LKNKP----------L 282
            .||            :..|...::||          ||....||.:|  ||:|.          |
  Rat   260 CNL------------VHEFTDAVIRE----------RRRTLPDQGLDEFLKSKAKSKTLDFIDVL 302

  Fly   283 MVSQSGESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVI-EKCN 346
            ::::..:...|:.|:|.|:|..|...|.:|:::.:.:.||.||::.:.|.|.|:|.||:: ::..
  Rat   303 LLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDP 367

  Fly   347 GELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKGMPVLIPCGAMHR 410
            .|:.::.:..|.:|...:.|:|||:..:.|::|.|.:|..:| |.   .|.||:..||....:|.
  Rat   368 EEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGR---TIPKGIICLISIFGIHH 429

  Fly   411 DEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVC 475
            :..::.:|..:||..|.||.:|:...:.::||..|||||||..|...:.::.|||.:..|:....
  Rat   430 NPSVWPDPEVYNPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPD 494

  Fly   476 EKTTIPMTYNKEMFLIASNSGIYLKAE 502
            :|.    ...:...::.:..|::|:.|
  Rat   495 DKE----PRRQPELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	118/511 (23%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	111/489 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900