DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	524	Identity:	127/524 - (24%)
Similarity:	222/524 - (42%)	Gaps:	72/524 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALVGYLLMKWRSTMRHWQDL----GIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRGS---- 69
            |.:.|.|:|  |.:..|::|    ||....|.|  |:....::...|......|..:|:.|
Zfish    23 AYITYQLLK--SYLHKWKELKPIPGIGNTFPFI--GNALQFKSNGDFFLQLVGYTTEFQNSPLLK 83

  Fly    70 ---GPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQ-LFLLDGQKWRT 130
               ||......|....|   ||.|...:.|.:...:.   |.|     |..|. |....|.|||.
Zfish    84 IWIGPIPFLILFHAETV---ETVLNNPVHIDKAYAYQ---FLH-----PWLGTGLLTSTGDKWRR 137

  Fly   131 MRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFT---TDVIGTCAFG 192
            .|..|:.||...    :....::|.||..:|..:.:.|..........:..|   .|:|...|.|
Zfish   138 RRKMLTPTFHFS----ILTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFSHITLCALDIICETAMG 198

  Fly   193 IECSSLKDPDAEF-REMGRRS---LTEQRLGPVGIGFVNSFPNLARRLHMKMTAEPIERFFMRIV 253
            ....:..:.|:|: |.:.|.|   ...||:......||.::....|..:..:  :.:..|...::
Zfish   199 KRIYAQSNYDSEYVRTVYRMSDIITRRQRMPWYWPDFVYNYVGEGREHNRSL--KILHSFTESVI 261

  Fly   254 RETVAF---------REQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFFAAG 309
            .|...:         .:|...:|..|:|.|:..|::        :...||.::|..:...|...|
Zfish   262 NERAEYLSYVESDSESDQGMRKRRAFLDMLLKTKDE--------DGKMLTHKDIQEEVDTFMFEG 318

  Fly   310 FETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVL 374
            .:|::..|.:|::.|..:.::|.:.::|..||..:....:|.|.:|.|.||:.|:.|:|||:..:
Zfish   319 HDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFGESERPVNTEDLKKLRYLECVIKESLRLFPSV 383

  Fly   375 PVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEW 439
            |...|...:|.::.|   :.:.||..:::...|:|||.:.:.:|..|.|:.|.||....|....:
Zfish   384 PFFARTICDDTQING---FKVPKGTNIVVITYALHRDPRFFPDPEEFRPERFLPENCVGRHPYAY 445

  Fly   440 LPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEM-----FLIASNSGIYL 499
            :||..|.|||||.||..|:.::.||.:::.|....|:|       .:|:     .::....||::
Zfish   446 IPFSAGLRNCIGQRFAIMEEKVILAYILRYFNIVACQK-------REELRPLGELVLRPEQGIWI 503

  Fly   500 KAER 503
            ..||
Zfish   504 TLER 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	116/492 (24%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	116/493 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900