DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	500	Identity:	134/500 - (26%)
Similarity:	249/500 - (49%)	Gaps:	49/500 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSM----KG-----VRTARSFNEIWTS 61
            ||:..||.:.|.    |  ..|.:..||||...|...:|::    ||     :..|:.:.::|
Zfish    15 VLVITLLFIYGV----W--PHRFFIKLGIPGPRPWPFVGTLLSYAKGLCNFDMECAKKYGKVW-- 71

  Fly    62 YYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDRGFFHNPEDDPLSGQLFLLDG 125
                        |.|..|.|.:.|.:..:.|.:|:|| ::.|.:|.........|.|..:.::..
Zfish    72 ------------GIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKD 124

  Fly   126 QKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGTCA 190
            ::|:.||:.||..||||::|.:||..:..|:.|.....:...:.| |:::|::|.::.|||.:.:
Zfish   125 ERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPEQP-VKIKEVVAPYSLDVITSSS 188

  Fly   191 FGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLA---RRLHMKMTAEPIERFFMRI 252
            |.::..|:.:|:..|....::.:......|: :..:..||:||   :::.:.:.::....||..:
Zfish   189 FSVDIDSINNPEDPFVINVKKFIQFNMFNPL-LLLILLFPSLAIPLKKMGVTLFSKSAMDFFYSV 252

  Fly   253 VRETVAFREQNNIRRNDFMDQLI--DLKNKPLMVSQSGE--SVNLTIEEIAAQAFVFFAAGFETS 313
            :::......:.:..|.||:..::  .:.:..:..|.:.|  :..||..||.:|:.||...|:||:
Zfish   253 LKKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFILGGYETT 317

  Fly   314 STTMGFALYELAQNQDIQNRVRKECQEVIEK---CNGELNYESMKDLVYLDQVVSETLRLYTVLP 375
            |||:.|.||.||.|.|...::.:|    |:|   .:..:.|:::..:.||:..::|::||....|
Zfish   318 STTLTFLLYNLATNPDCLEKLVEE----IDKNFPLDTPITYDALMRMDYLEMAINESMRLLPTAP 378

  Fly   376 VLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWL 440
            .|.|...:...:.|   ..|.:|..|.||...:..|..::.:|..|.|:.||||...|.....::
Zfish   379 RLERSAKKTVVING---LTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAFI 440

  Fly   441 PFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYN 485
            |||.|||||||||:..|..::.:..|:::|....|::|.||:..|
Zfish   441 PFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMN 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	123/470 (26%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	123/469 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.720