DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a21 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	517	Identity:	149/517 - (28%)
Similarity:	264/517 - (51%)	Gaps:	52/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRGSGPF 72
            |.|||.:.|    .|  ..|:::.||||..:.....|:|  :|....|:......:.|:   |..
Zfish    14 LAALLVIYG----SW--PHRYFKKLGIPGPKAIPFFGTM--LRYKDGFHVFDMDCFEKY---GRI 67

  Fly    73 AGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDRGFFHNPEDDPLSGQLF----LLDGQKWRTMR 132
            .|.|..|:|.:.:::.::.|.:|||| ::.||:|..|.      |:|.|:    :.:...||.:|
Zfish    68 WGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFR------LNGALYDAVSIAEDDDWRRIR 126

  Fly   133 NKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGTCAFGIECSS 197
            :.||.:||||::|.||..:.|.::...|..|:...:....:::|....::.||:.:.||.::..|
Zfish   127 SVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESADIKEFFGAYSMDVVTSTAFSVDIDS 191

  Fly   198 LKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLA---RRLHMKMTAEPIERFF------MRIV 253
            |.:|...|....::.|....|.|:.: .:..||.:|   .::...:....:..||      ::..
Zfish   192 LNNPKDPFVTNIKKMLKFDLLNPLFL-LIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSD 255

  Fly   254 RETVAFREQNNIRRNDFMDQLID----LKNKPLMVSQSGESV--NLTIEEIAAQAFVFFAAGFET 312
            |:|....:.|..:|.||:..::|    :|:|     ..||..  .|:..||.:|:.:|..||:||
Zfish   256 RDTKTVAKDNTKKRVDFLQLMVDSQTGVKHK-----SDGEHTEKGLSDHEILSQSMIFIFAGYET 315

  Fly   313 SSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVL 377
            ||:|:.|..|.||.|.:...::::|..|.... ...::||::..:.|||..:||:|||:.|...|
Zfish   316 SSSTLSFLFYNLATNPETMKKLQEEIDETFPN-QAPVDYETLMSMDYLDAALSESLRLFPVAARL 379

  Fly   378 NRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPF 442
            .|.|.:..|:.|   .:|.|.:.|::|..|:|||...::.|.:|.|:.|:....:..|...::||
Zfish   380 ERVCKKTVEING---LLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPF 441

  Fly   443 GDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMT--YNKEMFLIASNSGIYLKAE 502
            |.||||||||||.|:..::.:..:::.|..|||::|.:|:.  :|.   |::....|.||.:
Zfish   442 GLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFNG---LLSPKDPIKLKLQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	137/485 (28%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	138/487 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820