DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	163/512 - (31%)
Similarity:	275/512 - (53%)	Gaps:	34/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLTALLALVGYLLMKWRSTMRH---WQDLGIPCEEPH--ILMGSMKGV-RTARSFNEIWTSYYNK 65
            :.:.:|..|..|.:.|....||   |:..|.|.|: |  |..|.:..| |..:|........|.|
  Fly     1 MFSLILLAVTLLTLAWFYLKRHYEYWERRGFPFEK-HSGIPFGCLDSVWRQEKSMGLAIYDVYVK 64

  Fly    66 FRGSGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQLFLLDGQKWRT 130
            .:..  ..|.|...||||.:.:..||:::|.::|..|.|||.:.:.|.||||..:|.|.||.||:
  Fly    65 SKER--VLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLRGQSWRS 127

  Fly   131 MRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKS--PVVEVRELLARFTTDVIGTCAFGI 193
            ||:.||..|||||:|.||.|...:.::......:.:.:.  ..|::::::..:..|:|.:..||:
  Fly   128 MRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGL 192

  Fly   194 ECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHMKMTAEPIERFFMRIVRETVA 258
            :.:|.::||.:||::...:....|...:....:...|::|:.|.......|:....::||:|||.
  Fly   193 DVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIVKETVE 257

  Fly   259 FREQNNIRRNDFMDQLIDLKN---------KPLMVSQS--GESVNLTIEEIAAQAFVFFAAGFET 312
            :||::.|.|.|.:..||.|:|         |...:.::  |....:::|.|.||||:|:.||.||
  Fly   258 YREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYIAGQET 322

  Fly   313 SSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVL 377
            :.:|..|.:|||||..::..|::.|..|.:.|.:|::.|:|:..:.:||..|.||:|.|..||:|
  Fly   323 TGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQETIRKYPGLPIL 387

  Fly   378 NRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPF 442
            ||||.:||.|| ...:||.||.||:|....:|.|.:.:.:|.|::|:.|| |..:..:...::||
  Fly   388 NRECTQDYTVP-DTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFS-EESRNYNPTAFMPF 450

  Fly   443 GDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNSGIYL 499
            |:|||.||..|.|::.:::.:..::::|...|..::.|..          .||||.|
  Fly   451 GEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEF----------ENSGIAL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	154/479 (32%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	147/454 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461183
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900