DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	547	Identity:	134/547 - (24%)
Similarity:	221/547 - (40%)	Gaps:	108/547 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLTALLALVGYLLMKWR--STMRHWQDLGIPCEEPHILMGSMKGVR-TARSFNEI--WTSYYNK 65
            :.|..||.:|..|:::.:  .||..:     |....|.|.|.:|..| ......:|  |...|.
Zfish    20 IFLACLLTVVKLLIVRRKGVKTMERF-----PGPPAHWLFGHVKEFRQDGHDLEKIVKWMELYQ- 78

  Fly    66 FRGSGPFAGFYWFRRPAVFVL---ETSLAKQILIKEFNKFTDRGFFHNPEDD-------PLSGQ- 119
                  ||...|| .|::.||   ..|..|.||...           .|:||       |..|.
Zfish    79 ------FAFPLWF-GPSLAVLNIHHPSYVKTILTTT-----------EPKDDYAYKFFIPWLGDG 125

  Fly   120 LFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFT----DVFGQNVAKSPVVEVRELLAR 180
            |.:..||||...|..|:..|....:|    ..||:.::.|    |.:..:.......|:.:.::.
Zfish   126 LLVSTGQKWFRHRRLLTPGFHYDVLK----PYVKLISDSTKVMLDKWEVHSRSEESFELFKHVSL 186

  Fly   181 FTTDVIGTCAFGIECSSLKDPDA------------------EFREMGRRSLTEQRLGPVGIGFVN 227
            .|.|.|..|||  .|:|....|:                  .||.....|.....|.|.|..|
Zfish   187 MTLDSIMKCAF--SCNSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSPHGYRF-- 247

  Fly   228 SFPNLARRLHMKMTAEPIERFFMRIVRETVAFREQNNIRRN----DFMDQLIDLKNKPLMVSQSG 288
               ..|..:....|||.|     |..:|.:...|:..|.:|    ||:|.|:..:::    .|.|
Zfish   248 ---RKAASIAHNHTAEVI-----RKRKEVLKMEEEQGIVKNRRYLDFLDILLSARDE----HQQG 300

  Fly   289 ESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYES 353
                |:.|:|.|:...|...|.:|:::.:.:..|.||.|.:.|.:.|:|.|:.::. ...|.:|.
Zfish   301 ----LSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQALDG-KATLEWED 360

  Fly   354 MKDLVYLDQVVSETLRLYTVLPVLNREC------LEDYEVPGHPKYVIKKGMPVLIPCGAMHRDE 412
            :..:.|....:.|:|||:..:|.::|:.      .:...||        :|..:.:....:|.:.
Zfish   361 LNKIPYTTMCIKESLRLHPPVPGISRKLTKPLTFFDGRTVP--------EGCTIGVSIYGIHMNS 417

  Fly   413 KLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEK 477
            .::.||..|:|..|.||.|..|....::||..|||||||..|...:.::.:||.:|.: :.:.:.
Zfish   418 TVWENPYKFDPLRFLPENVANRSPHAFVPFSAGPRNCIGQNFAMNEMKVAVALTLKRY-YLIKDP 481

  Fly   478 TTIPMTYNKEMFLIASNSGIYLKAERV 504
            ...|...  ...::.|.:||::|.:.|
Zfish   482 DHTPKMI--PQVVLRSLNGIHIKIKPV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	125/509 (25%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	125/509 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900