DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp309a2

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	124/503 - (24%)
Similarity:	226/503 - (44%)	Gaps:	74/503 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIW--TSYYNKFRG 68
            ::|..||.|..||.:.|..  ::|:..|:....|..|:|:..|:.|.:| |.::  ...|:|::|
  Fly    40 LILLHLLVLPIYLYLTWHH--KYWRKRGLVTARPLTLLGTYPGLLTRKS-NLVFDVQKIYDKYKG 101

  Fly    69 SGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTD---RGFFHNPEDDPLSG-QLFLLDGQKWR 129
            .....|.:..|:|.:.||:..||.::|:..|..:.|   ..:..:.:.|..:. ..|...||.||
  Fly   102 KHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFWASGQSWR 166

  Fly   130 TMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVA-KSPVVEVRELLARFTTDVIGTCAFGI 193
            .:|....:..:..:::..:....:.....|:...|.|| |:.::|.|:|..|:|..|:....:||
  Fly   167 RLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHVMADFIWGI 231

  Fly   194 ECSSLKDP---DAEFREMGRR-------SLTEQRLGPVGIGFVNSFPNLARRLHMKMTAEPIE-- 246
            :..:|..|   ..:.:||..:       .||.         |:.:......||.::....|.|
  Fly   232 DAGTLTRPMEQPNKVQEMASKWTSYAFYMLTL---------FMATIVAPCSRLLLRFRFYPKETD 287

  Fly   247 RFFMRIVRETVAFR-EQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFFAAGF 310
            .||..:.:|::..| :..:..|.|::..|:.|:::.          ..|.:::...|......|:
  Fly   288 EFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQK----------QATHDDLVGHALTVMLDGY 342

  Fly   311 ETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKC---NGELNYESMKDLVYLDQVVSETLRLYT 372
            :||.|.:..|||.||:|..:|.::|.|    |..|   ...|::|.:..|.||:||:.|:|||.:
  Fly   343 DTSGTALLHALYYLAENPAVQQKLRVE----ILSCMASEKSLDFEKLSSLQYLEQVIYESLRLSS 403

  Fly   373 VLPVLNRECL------------EDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDN 425
            ::|...:.|.            .|.||          ||.::||....|.|::.:..|..|.|:.
  Fly   404 LIPQYTKVCTLPTVIRLSESKSLDVEV----------GMTIMIPNYQFHHDKQYFPEPEAFKPER 458

  Fly   426 FSPERVKE--RDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFK 471
            |.....:|  |..: :|||.||||.|:|:....:..:..|..::.:|:
  Fly   459 FDNGAYQELMRKGI-FLPFSDGPRICMGVPLAMLTLKSALVHILSNFQ 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	115/474 (24%)
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	115/471 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460991
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900