DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	504	Identity:	141/504 - (27%)
Similarity:	252/504 - (50%)	Gaps:	59/504 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGS----MKG-----VRTARSFNEIWTS 61
            ||:..||.:.|.    |....  ::.||||...|...:|:    .||     :..::.:.::|
Zfish    15 VLVITLLLIYGV----WPHGF--FKKLGIPGPRPLPFVGTALSYSKGICNFDIECSKKYGKVW-- 71

  Fly    62 YYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDRGFFHNPEDD---PLSGQLFL 122
                        |.|..|.|.:.|.:..:.|.||:|: ::.||:|   .|...|   |.:..:.|
Zfish    72 ------------GIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNR---RNMNPDLVGPFADGITL 121

  Fly   123 LDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSP---VVEVRELLARFTTD 184
            :..::||.:|:.||..||||::|.:||    :|....|.|.:|:.|..   .:::::::|.::.|
Zfish   122 VKDERWRRIRSSLSPYFTSGRLKEIFP----IAMTHADRFIKNMEKKDPNLPLKIKDVVAPYSLD 182

  Fly   185 VIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVG--IGFVNSFPNLARRLHMKMTAEPIER 247
            |:.:.:|.::..|:.:||..|....:.......|.|:.  :.|..|..||..::.:.:.:.....
Zfish   183 VVASSSFSVDFDSINNPDDPFVTSIKSFFNINPLSPLFLLLAFCPSAANLLAKMGISVFSRSTTD 247

  Fly   248 FFMRIVRETVAFREQNNIRRNDFMDQLI--DLKNKPLMVSQSGESV-NLTIEEIAAQAFVFFAAG 309
            |:.:.:|:......::| .|.||:..:|  .:.:..:..:.|.:.| .||..||.:|:|:|...|
Zfish   248 FYYKALRKIKDEHNESN-GRVDFLKLMIQNQIPDDQVKDTASEQPVKGLTDHEILSQSFIFILGG 311

  Fly   310 FETSSTTMGFALYELAQNQDIQNRVRKECQEVIEK---CNGELNYESMKDLVYLDQVVSETLRLY 371
            :||:|||:.:.||.||.|.|...::.:|    |:|   .:..:.|:::..:.||:..:.|::|::
Zfish   312 YETTSTTLSYLLYNLATNPDCLEKLVEE----IDKNFPLDIPITYDALMRMDYLEMAIHESMRVF 372

  Fly   372 TVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDS 436
            ...|.|.|.|.:..|:.|   ..|.|...|.||...:.||..|:.:||.|.|:.||||...|.:.
Zfish   373 PAGPRLERVCKKTVEING---ITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKTEINQ 434

  Fly   437 VEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYN 485
            ..::|||.||||||||||..|..::.:..|::.:....|::|.||:..|
Zfish   435 CAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQLN 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	132/475 (28%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	132/475 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.810