Protein Alignment Cyp6a21 and Cyp26c1

DIOPT Version :10

• Sequence 1: NP_611003.2
• Gene: Cyp6a21 / 36665
• FlyBaseID: FBgn0288232
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_217935.3
• Gene: Cyp26c1 / 308190
• RGDID: 1308843
• Length: 518
• Species: Rattus norvegicus
• Alignment Length: 558
• Identity: 120/558 - (21%)
• Similarity: 204/558 - (36%)
• Gaps: 137/558 - (24%)

  Fly     2 SVGTVLLTA--LLALVGYL-LMKWRSTMRHW-QDLGIPCEEPHILMGSMKGVRTARSFNEI--WT 60
            :.||.||.|  ||.|...| .::| :..|.| ..|.:|           ||......|.|.  |.
  Rat    14 AAGTALLCAGLLLGLAQQLWTLRW-TLSRDWASTLPLP-----------KGSMGWPFFGETLHWL 66

  Fly    61 SYYNKFRGS-----GPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQL 120
            ...::|..|     |.....:...||.:.|......:.||:.|......:.        |.|..:
  Rat    67 VQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQW--------PQSAHI 123

  Fly   121 FL-------LDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELL 178
            .|       ..|::.|..|..|:..|:...::...|.:.:....  :|.....|:.||. |.:..
  Rat   124 LLGSHTLLGAVGERHRQRRKVLARVFSRPALEQFVPRLQEALRR--EVRSWCAAQRPVA-VYQAA 185

  Fly   179 ARFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHMKMTAE 243
            ...|..:......|::                  |.|.|...:...|        .||...:.:.
  Rat   186 KALTFRMAARILLGLQ------------------LDEARCTELAQTF--------ERLVENLFSL 224

  Fly   244 PIERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTI-------EEIAAQ 301
            |::..|..: |:.:..|:|    ....:|::|..|.:..:.::.|::::|.|       .|::.|
  Rat   225 PLDVPFSGL-RKGIRARDQ----LYQHLDEVIAEKLREELTAEPGDALHLIINSARELGRELSVQ 284

  Fly   302 AF------VFFAAGFETSSTTMGFALYEL---AQNQDIQNRV------------------RKECQ 339
            ..      :.|||.|.|:|.:....|..|   |....||..:                  |.:|
  Rat   285 ELKELAVELLFAAFFTTASASTSLILLLLQHPAAIAKIQQELSAQGLGSPCSCAPRASGSRPDC- 348

  Fly   340 EVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLN---RECLEDYEVPGHPKYVIKKGMPV 401
                .|..:|:...:..|.|:|.||.|.|||   ||.::   |..|..:|:.|   |.|.||..|
  Rat   349 ----SCEPDLSLAVLGRLRYVDCVVKEVLRL---LPPVSGGYRTALRTFELDG---YQIPKGWSV 403

  Fly   402 LIPCGAMHRDEKLYANPNTFNPDNFSPER--VKERDS------VEWLPFGDGPRNCIGMRFGQMQ 458
            :......|....:|.:|    |:.|.|||  |:..|:      ..::|||.|.|:|:|....|..
  Rat   404 MYSIRDTHETAAVYRSP----PEGFDPERFGVESEDARGSGGRFHYIPFGGGARSCLGQELAQAV 464

  Fly   459 ARIGLALLIKDFKFSVCEKT-----TIPMTYNKEMFLI 491
            .::....|::..::.:....     |:|:.:..:..|:
  Rat   465 LQLLAVELVRTARWELATPAFPVMQTVPIVHPVDGLLL 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	CYP6-like	68..498	CDD:410679	100/486 (21%)
Cyp26c1	XP_217935.3	cytochrome_P450	59..504	CDD:477761	104/501 (21%)