Protein Alignment Cyp6a21 and Cyp4a3

DIOPT Version :10

• Sequence 1: NP_611003.2
• Gene: Cyp6a21 / 36665
• FlyBaseID: FBgn0288232
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_038965516.1
• Gene: Cyp4a3 / 298423
• RGDID: 631356
• Length: 511
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 127/540 - (23%)
• Similarity: 223/540 - (41%)
• Gaps: 89/540 - (16%)

  Fly     4 GTVLLTALLALVG----YLLMKW--------RSTMRHWQDLGIPCEEPHILMG-SMKGVRTARSF 55
            |..||:..|.|..    ||..:|        .||..||            |.| .:|.    |.|
  Rat    21 GAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHW------------LWGHDLKD----REF 69

  Fly    56 NEIWTSYYNKFRGSGPFAGFYWF--RRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSG 118
            .::.| :..||    |.|...|.  .:..|.:.:....|.:|.:...|.:  |.:.......:||
  Rat    70 QQVLT-WVEKF----PGACLQWLSGSKTRVLLYDPDYVKVVLGRSDPKAS--GIYQFLAPWIVSG 127

  Fly   119 Q---LFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLAR 180
            .   |.||:|:||......|:..|..|.:|.....:....:...|.:.:...:...:|:...::.
  Rat   128 TGYGLLLLNGKKWFQHWRMLTPAFHYGILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSL 192

  Fly   181 FTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGF--------VNSFPNLARRL- 236
            .|.|.:..|||..:.|...|.::.........|.......|...|        ::|...|:||.
  Rat   193 MTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLTFFRVRSAFYGNSIIYNMSSDGRLSRRAC 257

  Fly   237 -----H----MKMTAEPIERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVN 292
                 |    :||....::.     ..|....|::.::   ||:|.|:..|      .:.|:|
  Rat   258 QIAHEHTDGVIKMRKAQLQN-----EEELQKARKKRHL---DFLDILLFAK------MEDGKS-- 306

  Fly   293 LTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGE---LNYESM 354
            |:.|::.|:...|...|.:|:::.:.:..|.||.:.:.|.|.|:|.|.::    |:   :.::.:
  Rat   307 LSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSIL----GDGTSVTWDHL 367

  Fly   355 KDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPN 419
            ..:.|....:.|.||||..:|.::||.......|....  |.||:...|....:|.:...:.||.
  Rat   368 DQISYTTMCIKEALRLYPPVPSVSRELSSPVTFPDGRS--IPKGITTTILIYGLHHNPSYWPNPK 430

  Fly   420 TFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTY 484
            .|:|..|||:  ..|.|..:|||..|.|||||.:|...:.::.:||.:..|:. :.:.|.||:..
  Rat   431 VFDPSRFSPD--SPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL-LPDPTRIPVPM 492

  Fly   485 NKEMFLIASNSGIYLKAERV 504
            .:  .::.|.:||:|:.:::
  Rat   493 AR--LVLKSKNGIHLRLKKL 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	CYP6-like	68..498	CDD:410679	105/455 (23%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	110/470 (23%)