DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a21 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	127/540 - (23%)
Similarity:	223/540 - (41%)	Gaps:	89/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GTVLLTALLALVG----YLLMKW--------RSTMRHWQDLGIPCEEPHILMG-SMKGVRTARSF 55
            |..||:..|.|..    ||..:|        .||..||            |.| .:|.    |.|
  Rat    21 GAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHW------------LWGHDLKD----REF 69

  Fly    56 NEIWTSYYNKFRGSGPFAGFYWF--RRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSG 118
            .::.| :..||    |.|...|.  .:..|.:.:....|.:|.:...|.:  |.:.......:||
  Rat    70 QQVLT-WVEKF----PGACLQWLSGSKTRVLLYDPDYVKVVLGRSDPKAS--GIYQFLAPWIVSG 127

  Fly   119 Q---LFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLAR 180
            .   |.||:|:||......|:..|..|.:|.....:....:...|.:.:...:...:|:...::.
  Rat   128 TGYGLLLLNGKKWFQHWRMLTPAFHYGILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSL 192

  Fly   181 FTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGF--------VNSFPNLARRL- 236
            .|.|.:..|||..:.|...|.::.........|.......|...|        ::|...|:||.
  Rat   193 MTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLTFFRVRSAFYGNSIIYNMSSDGRLSRRAC 257

  Fly   237 -----H----MKMTAEPIERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVN 292
                 |    :||....::.     ..|....|::.::   ||:|.|:..|      .:.|:|
  Rat   258 QIAHEHTDGVIKMRKAQLQN-----EEELQKARKKRHL---DFLDILLFAK------MEDGKS-- 306

  Fly   293 LTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGE---LNYESM 354
            |:.|::.|:...|...|.:|:::.:.:..|.||.:.:.|.|.|:|.|.::    |:   :.::.:
  Rat   307 LSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSIL----GDGTSVTWDHL 367

  Fly   355 KDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPN 419
            ..:.|....:.|.||||..:|.::||.......|....  |.||:...|....:|.:...:.||.
  Rat   368 DQISYTTMCIKEALRLYPPVPSVSRELSSPVTFPDGRS--IPKGITTTILIYGLHHNPSYWPNPK 430

  Fly   420 TFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTY 484
            .|:|..|||:  ..|.|..:|||..|.|||||.:|...:.::.:||.:..|:. :.:.|.||:..
  Rat   431 VFDPSRFSPD--SPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL-LPDPTRIPVPM 492

  Fly   485 NKEMFLIASNSGIYLKAERV 504
            .:  .::.|.:||:|:.:::
  Rat   493 AR--LVLKSKNGIHLRLKKL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	114/490 (23%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	110/470 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900