DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	406	Identity:	99/406 - (24%)
Similarity:	184/406 - (45%)	Gaps:	37/406 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 LSGQLFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQN-----VAKSPVVEVR 175
            |...|||..|.||...|..|:..|....:|    ..||:.|:..::....     :..|..:|:.
  Rat   132 LGDGLFLSSGDKWSRHRRLLTPAFHFDILK----PYVKIFNQSVNIMHAKWKHLCLEGSARLEMF 192

  Fly   176 ELLARFTTDVIGTCAFGIECSSLKDPD---AEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLH 237
            |.::..|.|.:..|.||.:.:..:.|.   :...|:.  ||..:|...:.:.....:...|....
  Rat   193 ENISLMTLDSLQKCLFGFDSNCQESPSEYISAILELS--SLIIKRSQQLFLYLDFLYYRTADGRR 255

  Fly   238 MKMTAEPIERFFMRIVRE---------TVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNL 293
            .:...:.:..|...::||         |..|.|.....::..:| .||:    |::::......|
  Rat   256 FRKACDLVHNFTDAVIRERRRLLSSQGTDEFLESKTKSKSKTLD-FIDV----LLLAKDEHGKEL 315

  Fly   294 TIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVI-EKCNGELNYESMKDL 357
            :.|:|.|:|..|...|.:|:::.:.:.||.||::.:.|.|.|:|..|:: ::...|:.::.:..|
  Rat   316 SDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDLAQL 380

  Fly   358 VYLDQVVSETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTF 421
            .:|...:.|:|||:.....|.|.|.:|..:| |.   ||.||...:|....:|.:..::.:|..|
  Rat   381 PFLTMCIKESLRLHPPAIDLLRRCTQDIVLPDGR---VIPKGNICVISIFGIHHNPSVWPDPEVF 442

  Fly   422 NPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNK 486
            :|..|..|..::|..:.::||..|||||||..|...:.::.:||.:  .:|.|......|.  .|
  Rat   443 DPFRFDSENRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTL--LRFRVLPDDKEPR--RK 503

  Fly   487 EMFLIASNSGIYLKAE 502
            ...::.:..|::|:.|
  Rat   504 PEIILRAEGGLWLRME 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	97/401 (24%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	97/401 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900